Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis.
To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate a...
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doaj-7ac676b8ce984dcbadc0720af90b8e642020-11-25T02:24:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6919010.1371/journal.pone.0069190Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis.Alisdair McNeillRuey-Meei WuKai-Yuan TzenPatricia C AguiarJose M ArbeloPaolo BaroneKailash BhatiaOrlando BarsottiniVincenzo BonifatiSevasti BostantjopoulouRodrigo BressanGiovanni CossuPietro CortelliAndre FelicioHenrique B FerrazJoanna HerreraHenry HouldenMarcelo HoexterConcepcion IslaAndrew LeesOswaldo Lorenzo-BetancorNiccolo E MencacciPau PastorSabina PappataMaria Teresa PellecchiaLaura Silveria-MoriyamaAndrea VarroneTom FoltynieAnthony H V SchapiraTo compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.http://europepmc.org/articles/PMC3720622?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alisdair McNeill Ruey-Meei Wu Kai-Yuan Tzen Patricia C Aguiar Jose M Arbelo Paolo Barone Kailash Bhatia Orlando Barsottini Vincenzo Bonifati Sevasti Bostantjopoulou Rodrigo Bressan Giovanni Cossu Pietro Cortelli Andre Felicio Henrique B Ferraz Joanna Herrera Henry Houlden Marcelo Hoexter Concepcion Isla Andrew Lees Oswaldo Lorenzo-Betancor Niccolo E Mencacci Pau Pastor Sabina Pappata Maria Teresa Pellecchia Laura Silveria-Moriyama Andrea Varrone Tom Foltynie Anthony H V Schapira |
spellingShingle |
Alisdair McNeill Ruey-Meei Wu Kai-Yuan Tzen Patricia C Aguiar Jose M Arbelo Paolo Barone Kailash Bhatia Orlando Barsottini Vincenzo Bonifati Sevasti Bostantjopoulou Rodrigo Bressan Giovanni Cossu Pietro Cortelli Andre Felicio Henrique B Ferraz Joanna Herrera Henry Houlden Marcelo Hoexter Concepcion Isla Andrew Lees Oswaldo Lorenzo-Betancor Niccolo E Mencacci Pau Pastor Sabina Pappata Maria Teresa Pellecchia Laura Silveria-Moriyama Andrea Varrone Tom Foltynie Anthony H V Schapira Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. PLoS ONE |
author_facet |
Alisdair McNeill Ruey-Meei Wu Kai-Yuan Tzen Patricia C Aguiar Jose M Arbelo Paolo Barone Kailash Bhatia Orlando Barsottini Vincenzo Bonifati Sevasti Bostantjopoulou Rodrigo Bressan Giovanni Cossu Pietro Cortelli Andre Felicio Henrique B Ferraz Joanna Herrera Henry Houlden Marcelo Hoexter Concepcion Isla Andrew Lees Oswaldo Lorenzo-Betancor Niccolo E Mencacci Pau Pastor Sabina Pappata Maria Teresa Pellecchia Laura Silveria-Moriyama Andrea Varrone Tom Foltynie Anthony H V Schapira |
author_sort |
Alisdair McNeill |
title |
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. |
title_short |
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. |
title_full |
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. |
title_fullStr |
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. |
title_full_unstemmed |
Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. |
title_sort |
dopaminergic neuronal imaging in genetic parkinson's disease: insights into pathogenesis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss. |
url |
http://europepmc.org/articles/PMC3720622?pdf=render |
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