Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation
Objective: To study the curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation. Methods: A total of 104 patients diagnosed with gestational diabetes mellitus in our hosp...
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Editorial Board of Journal of Hainan Medical University
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doaj-7ac841f05a9d4b4fa1c71a41a88f21b22020-11-25T00:33:06ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372016-12-0122243841Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammationFen-Xia Li0Qiu-Ping Jia1Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Xi'an Medical University, Xi'an City, Shaanxi Province, 710038Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Xi'an Medical University, Xi'an City, Shaanxi Province, 710038Objective: To study the curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation. Methods: A total of 104 patients diagnosed with gestational diabetes mellitus in our hospital between March 2013 and July 2016 were selected and randomly divided into two groups, VitD group received insulin aspart combined with vitamin D therapy and control group received insulin aspart therapy. 1 month after treatment, insulin resistance, umbilical artery flow parameters as well as serum content of NO, ET-1, adipocytokines and inflammatory cytokines were evaluated. Results: 1 month after treatment, HOMA-βand HOMA-IR of VitD group were significantly lower than those of control group while ISIcomp was significantly higher than that of control group, umbilical artery RI, PI and S/D levels were significantly lower than those of control group, and serum leptin, visfatin, chemerin, IL-1, IL-2, IL-3, IL-6, IL-10 and ET-1 content of VitD group were significantly lower than those of control group while adiponectin, omentin and NO content were significantly higher than those of control group. Conclusion: Insulin aspart combined with vitamin D therapy can relieve the insulin resistance, reduce the umbilical blood flow resistance and adjust the secretion of adipocytokines and inflammatory cytokines in patients with gestational diabetes mellitus.http://www.hnykdxxb.com/PDF/201624/10.pdfGestational diabetes mellitusInsulin resistanceVitamin DAdipocytokinesInflammatory cytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fen-Xia Li Qiu-Ping Jia |
spellingShingle |
Fen-Xia Li Qiu-Ping Jia Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation Journal of Hainan Medical University Gestational diabetes mellitus Insulin resistance Vitamin D Adipocytokines Inflammatory cytokines |
author_facet |
Fen-Xia Li Qiu-Ping Jia |
author_sort |
Fen-Xia Li |
title |
Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation |
title_short |
Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation |
title_full |
Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation |
title_fullStr |
Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation |
title_full_unstemmed |
Curative effect of insulin aspart combined with vitamin D therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation |
title_sort |
curative effect of insulin aspart combined with vitamin d therapy for gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines and inflammation |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2016-12-01 |
description |
Objective: To study the curative effect of insulin aspart combined with vitamin D therapy for
gestational diabetes mellitus and its effect on umbilical blood flow resistance, adipocytokines
and inflammation. Methods: A total of 104 patients diagnosed with gestational diabetes
mellitus in our hospital between March 2013 and July 2016 were selected and randomly
divided into two groups, VitD group received insulin aspart combined with vitamin D therapy
and control group received insulin aspart therapy. 1 month after treatment, insulin resistance,
umbilical artery flow parameters as well as serum content of NO, ET-1, adipocytokines and
inflammatory cytokines were evaluated. Results: 1 month after treatment, HOMA-βand
HOMA-IR of VitD group were significantly lower than those of control group while ISIcomp
was significantly higher than that of control group, umbilical artery RI, PI and S/D levels were
significantly lower than those of control group, and serum leptin, visfatin, chemerin, IL-1,
IL-2, IL-3, IL-6, IL-10 and ET-1 content of VitD group were significantly lower than those of
control group while adiponectin, omentin and NO content were significantly higher than those
of control group. Conclusion: Insulin aspart combined with vitamin D therapy can relieve
the insulin resistance, reduce the umbilical blood flow resistance and adjust the secretion of
adipocytokines and inflammatory cytokines in patients with gestational diabetes mellitus. |
topic |
Gestational diabetes mellitus Insulin resistance Vitamin D Adipocytokines Inflammatory cytokines |
url |
http://www.hnykdxxb.com/PDF/201624/10.pdf |
work_keys_str_mv |
AT fenxiali curativeeffectofinsulinaspartcombinedwithvitamindtherapyforgestationaldiabetesmellitusanditseffectonumbilicalbloodflowresistanceadipocytokinesandinflammation AT qiupingjia curativeeffectofinsulinaspartcombinedwithvitamindtherapyforgestationaldiabetesmellitusanditseffectonumbilicalbloodflowresistanceadipocytokinesandinflammation |
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