Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study
Objective:The aim of our study was to compare plasma vitamin D levels between patients with breast cancer-related lymphedema (BCRL) and healthy population, and also to investigate the effects of socio-demographic and clinical factors and lymphedema severity on vitamin D levels.Materials and Methods:...
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Galenos Yayinevi
2019-12-01
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doaj-7ac946795bd3489bbfe68e57cac16ae22020-11-25T03:57:36ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532147-26532019-12-0125310511010.4274/tod.galenos.2019.3511913049054Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional StudyDidem Sezgin Özcan0Meltem Dalyan1Serhat Ergül2Sibel Ünsal Delialioğlu3Belma Füsun Köseoğlu4 İstanbul Medipol University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, İstanbul, Turkey Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Clinic of Physical Medicine and Rehabilitation, Ankara, Turkey Diyarbakır Gazi Yaşargil Training and Research Hospital, Clinic of Physical Medicine and Rehabilitation, Diyarbakır, Turkey Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Clinic of Physical Medicine and Rehabilitation, Ankara, Turkey TOBB ETU Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey Objective:The aim of our study was to compare plasma vitamin D levels between patients with breast cancer-related lymphedema (BCRL) and healthy population, and also to investigate the effects of socio-demographic and clinical factors and lymphedema severity on vitamin D levels.Materials and Methods:Eighty patients with BCRL [mean age 55.5±8.9 (36-81)] and age- and sex-matched 80 healthy controls [mean age 53.7±7.4 (32-70)] who were not on calcium or vitamin D supplementation were included in the study. Socio-demographic and clinical characteristics of the subjects were questioned. Plasma 25-Hydroxyvitamin D3, calcium, phosphorus, alkaline phosphatase (ALP), and parathormone (PTH) levels were evaluated. Lymphedema was classified as stage 0, I, II, or III.Results:The mean duration of lymphedema was 23.5±13.8 months. Comparisons revealed lower vitamin D levels and higher PTH and ALP levels in patients with BCRL than healthy controls. As a result of multivariate regression analysis, a significant relationship was revealed between vitamin D levels and age, breast cancer stage, and disease duration in patients with BCRL. Vitamin D levels were significantly lower and PTH levels were significantly higher in stage 3 lymphedema patients compared to stage 1.Conclusion:Vitamin D levels were detected lower in patients with lymphedema than healthy controls. Although vitamin D levels were found to be lower in patients with severe lymphedema, the multivariate regression analysis revealed that the severity of lymphedema does not have a significant effect on vitamin D levels. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/evaluation-of-vitamin-d-levels-in-patients-with-br/30586 vitamin dbreast cancerlymphedemaparathormone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Didem Sezgin Özcan Meltem Dalyan Serhat Ergül Sibel Ünsal Delialioğlu Belma Füsun Köseoğlu |
spellingShingle |
Didem Sezgin Özcan Meltem Dalyan Serhat Ergül Sibel Ünsal Delialioğlu Belma Füsun Köseoğlu Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study Türk Osteoporoz Dergisi vitamin d breast cancer lymphedema parathormone |
author_facet |
Didem Sezgin Özcan Meltem Dalyan Serhat Ergül Sibel Ünsal Delialioğlu Belma Füsun Köseoğlu |
author_sort |
Didem Sezgin Özcan |
title |
Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study |
title_short |
Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study |
title_full |
Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study |
title_fullStr |
Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study |
title_full_unstemmed |
Evaluation of Vitamin D Levels in Patients with Breast Cancer-related Lymphedema: An Observational Cross-sectional Study |
title_sort |
evaluation of vitamin d levels in patients with breast cancer-related lymphedema: an observational cross-sectional study |
publisher |
Galenos Yayinevi |
series |
Türk Osteoporoz Dergisi |
issn |
2147-2653 2147-2653 |
publishDate |
2019-12-01 |
description |
Objective:The aim of our study was to compare plasma vitamin D levels between patients with breast cancer-related lymphedema (BCRL) and healthy population, and also to investigate the effects of socio-demographic and clinical factors and lymphedema severity on vitamin D levels.Materials and Methods:Eighty patients with BCRL [mean age 55.5±8.9 (36-81)] and age- and sex-matched 80 healthy controls [mean age 53.7±7.4 (32-70)] who were not on calcium or vitamin D supplementation were included in the study. Socio-demographic and clinical characteristics of the subjects were questioned. Plasma 25-Hydroxyvitamin D3, calcium, phosphorus, alkaline phosphatase (ALP), and parathormone (PTH) levels were evaluated. Lymphedema was classified as stage 0, I, II, or III.Results:The mean duration of lymphedema was 23.5±13.8 months. Comparisons revealed lower vitamin D levels and higher PTH and ALP levels in patients with BCRL than healthy controls. As a result of multivariate regression analysis, a significant relationship was revealed between vitamin D levels and age, breast cancer stage, and disease duration in patients with BCRL. Vitamin D levels were significantly lower and PTH levels were significantly higher in stage 3 lymphedema patients compared to stage 1.Conclusion:Vitamin D levels were detected lower in patients with lymphedema than healthy controls. Although vitamin D levels were found to be lower in patients with severe lymphedema, the multivariate regression analysis revealed that the severity of lymphedema does not have a significant effect on vitamin D levels. |
topic |
vitamin d breast cancer lymphedema parathormone |
url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/evaluation-of-vitamin-d-levels-in-patients-with-br/30586
|
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