Study of Maternal Diabetic Effects on Malformation Production in Rat’s Fetus
The studies show that there are some embryonic malformation in maternal diabetic rats. This malformation may be manifestation in other embryonic organs such as skeletal cardiovascular or centeral nervus system. In this study the effects of the maternal hyperglicemia on the processes of ...
| Main Authors: | , |
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| Format: | Article |
| Language: | fas |
| Published: |
Hamadan University of Medical Sciences
2002-09-01
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| Series: | پزشکی بالینی ابن سینا |
| Subjects: | |
| Online Access: | http://sjh.umsha.ac.ir/article-1-740-en.html |
| Summary: | The studies show that there are some embryonic malformation in
maternal diabetic rats. This malformation may be manifestation in other
embryonic organs such as skeletal cardiovascular or centeral nervus system.
In this study the effects of the maternal hyperglicemia on the processes of
embryonic evolution, during rat,s pregnancy were investigated.
For this aim the beta cells of pancreas of 7 virgin albino rats were
chemically destroyed by an injection of 160 mg/Kg alloxan and the same
manner control group were recived physiological serum. The hyperglicemic
rats were then mated and at 14th gestational day’s , all of the pregnant
rats anesthetized, sacrificed and their fetuses were collected and fixed in
10% formalin solution. After fixation, all of the fetuses were examined by
using the stereomicroscope.
Comparing the experimental with the control group, showed a
numerical decrease in experimental group. In addition, the length of
Crown-Rump (CR) were decreased significantly in experimental fetuses
(p<0.001). The rate of the many malformation such as deffect in eyes, ears
and craniofascial deffect and exencephaly were shown in experimental
kinds.
These results suggest that the maternal diabetic may cause some of
fetal malformations during pregnancy. |
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| ISSN: | 2588-722X 2588-7238 |