The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran
OBJECTIVES Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971. METHODS The present...
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Korean Society of Epidemiology
2018-10-01
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doaj-7acd0e7718d64c4ba092069181f2a2e32020-11-24T23:08:16ZengKorean Society of Epidemiology Epidemiology and Health2092-71932018-10-014010.4178/epih.e20180481001The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in IranAlireza Ansari-Moghaddam0Hossein Ali Adineh1Iraj Zareban2Mehdi Mohammadi3Mahtab Maghsoodlu4 Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Department of Epidemiology and Biostatistics, Iranshahr University of Medical Sciences, Iranshahr, Iran Department of Health Education, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Research Center, Iran Blood Transfusion Organization, Tehran, IranOBJECTIVES Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971. METHODS The present historical cohort study extracted data from the health records of patients with beta-thalassemia major, beta-thalassemia intermedia, and sickle beta-thalassemia who had presented to thalassemia treatment centers in the past years. The collected data were analyzed using the Kaplan-Meier test, the log-rank test, and the chi-square test. RESULTS Of the total of 5,491 medical records (2,647 men and 2,634 women; mean age, 23.81±11.32 years), 3,936 belonged to patients with beta-thalassemia major, and 999 and 89 to patients with beta-thalassemia intermedia and sickle beta-thalassemia, respectively. In 467 cases, the type of thalassemia was not clear. The cumulative survival rate was calculated as 0.92, 0.83, 0.74, and 0.51 by ages 25, 35, 45, and 55, respectively. The hazard ratio of death was 4.22 (p<0.05) for beta-thalassemia major and 0.77 for beta-thalassemia intermedia (p=0.70). It was calculated as 1.45 for men patients and as 3.82 for single patients. CONCLUSIONS The present study showed relatively high survival rates in patients with thalassemia. The survival of patients was unfavorable in poorer regions (Zahedan and Iranshahr). Factors including women gender, a higher level of education, being married, and living in metropolises decreased the risk of death at younger ages and improved survival.http://www.e-epih.org/upload/pdf/epih-40-e2018048.pdfBeta-thalassemiaGenderPrevalenceSurvivalIran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alireza Ansari-Moghaddam Hossein Ali Adineh Iraj Zareban Mehdi Mohammadi Mahtab Maghsoodlu |
spellingShingle |
Alireza Ansari-Moghaddam Hossein Ali Adineh Iraj Zareban Mehdi Mohammadi Mahtab Maghsoodlu The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran Epidemiology and Health Beta-thalassemia Gender Prevalence Survival Iran |
author_facet |
Alireza Ansari-Moghaddam Hossein Ali Adineh Iraj Zareban Mehdi Mohammadi Mahtab Maghsoodlu |
author_sort |
Alireza Ansari-Moghaddam |
title |
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran |
title_short |
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran |
title_full |
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran |
title_fullStr |
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran |
title_full_unstemmed |
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran |
title_sort |
survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in iran |
publisher |
Korean Society of Epidemiology |
series |
Epidemiology and Health |
issn |
2092-7193 |
publishDate |
2018-10-01 |
description |
OBJECTIVES Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971. METHODS The present historical cohort study extracted data from the health records of patients with beta-thalassemia major, beta-thalassemia intermedia, and sickle beta-thalassemia who had presented to thalassemia treatment centers in the past years. The collected data were analyzed using the Kaplan-Meier test, the log-rank test, and the chi-square test. RESULTS Of the total of 5,491 medical records (2,647 men and 2,634 women; mean age, 23.81±11.32 years), 3,936 belonged to patients with beta-thalassemia major, and 999 and 89 to patients with beta-thalassemia intermedia and sickle beta-thalassemia, respectively. In 467 cases, the type of thalassemia was not clear. The cumulative survival rate was calculated as 0.92, 0.83, 0.74, and 0.51 by ages 25, 35, 45, and 55, respectively. The hazard ratio of death was 4.22 (p<0.05) for beta-thalassemia major and 0.77 for beta-thalassemia intermedia (p=0.70). It was calculated as 1.45 for men patients and as 3.82 for single patients. CONCLUSIONS The present study showed relatively high survival rates in patients with thalassemia. The survival of patients was unfavorable in poorer regions (Zahedan and Iranshahr). Factors including women gender, a higher level of education, being married, and living in metropolises decreased the risk of death at younger ages and improved survival. |
topic |
Beta-thalassemia Gender Prevalence Survival Iran |
url |
http://www.e-epih.org/upload/pdf/epih-40-e2018048.pdf |
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