Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis
We aimed to compare the sonographic measurement of median nerve cross-section area (CSA) in patients with Amyotrophic Lateral Sclerosis (ALS) and healthy individuals. The effect of duration of the disease on correlations between paraclinical findings and ALS functional rating scale (ALSFRS) were se...
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doaj-7ad108b5ef4d48fbad9da9c6d4723ef32020-11-25T03:42:33ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942020-05-01571110.18502/acta.v57i11.32648020Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral SclerosisParvaneh Deilami0Shadi Ghourchian1Bahram Haghi Ashtiani2Sara Esmaeili3Maryam Bahadori4Seyedeh Fahimeh Shojaei5Mohammad Reza Babaei6Leila Raeesmohammadi7Motahare Afrakhteh8Babak Zamani9Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Deprtment of Neurology, School of Medicine, University of Maryland, Baltimore, MD, US.Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranDepartment of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Psychiatry, Firoozgar Clinical Research and Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran,Department of Interventional Radiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. We aimed to compare the sonographic measurement of median nerve cross-section area (CSA) in patients with Amyotrophic Lateral Sclerosis (ALS) and healthy individuals. The effect of duration of the disease on correlations between paraclinical findings and ALS functional rating scale (ALSFRS) were secondarily aimed to be evaluated. The cross-sectional study was approved by the Ethical Committee of Iran University of Medical Sciences and conducted between January 2017 and December 2018. We evaluated the median nerve surface area by means of sonography in 35 ALS patients and 35 healthy controls. Compound muscle action potential (CMAP) amplitudes during nerve conduction study and ALSFRS were recorded by the same trained specialist. Data were analyzed using SPSS software version 18. We did not find a significant difference between CSA in ALS patients and the normal population (P>0.05). Comparing to normal individuals, the mean CMAP decreased significantly in ALS patients (6.6±3.07 mV versus 10.25±2.2 mV, P<0.001). ALSFRS correlated with both CSA of the median nerve at the wrist (P:<0.001, r:0.78) and the CMAP (P:<0.001, r:0.74) that were confirmed by regression models designed to consider the effect of disease duration on these correlations. CSA was not different between ALS patients and the normal population, but CMAP decreased in ALS patients. ALSFRS correlated with both CSA and CMAP of the median nerve. https://acta.tums.ac.ir/index.php/acta/article/view/8020Amyotrophic lateral sclerosis (ALS)Median nerveCross-sectional areaCompound muscle action potential (CMAP)ALS functional rating scale (ALSFRS) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parvaneh Deilami Shadi Ghourchian Bahram Haghi Ashtiani Sara Esmaeili Maryam Bahadori Seyedeh Fahimeh Shojaei Mohammad Reza Babaei Leila Raeesmohammadi Motahare Afrakhteh Babak Zamani |
spellingShingle |
Parvaneh Deilami Shadi Ghourchian Bahram Haghi Ashtiani Sara Esmaeili Maryam Bahadori Seyedeh Fahimeh Shojaei Mohammad Reza Babaei Leila Raeesmohammadi Motahare Afrakhteh Babak Zamani Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis Acta Medica Iranica Amyotrophic lateral sclerosis (ALS) Median nerve Cross-sectional area Compound muscle action potential (CMAP) ALS functional rating scale (ALSFRS) |
author_facet |
Parvaneh Deilami Shadi Ghourchian Bahram Haghi Ashtiani Sara Esmaeili Maryam Bahadori Seyedeh Fahimeh Shojaei Mohammad Reza Babaei Leila Raeesmohammadi Motahare Afrakhteh Babak Zamani |
author_sort |
Parvaneh Deilami |
title |
Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis |
title_short |
Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis |
title_full |
Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis |
title_fullStr |
Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis |
title_full_unstemmed |
Correlations Between Median Nerve Sonography and Conduction Study Results and Functional Scales in Amyotrophic Lateral Sclerosis |
title_sort |
correlations between median nerve sonography and conduction study results and functional scales in amyotrophic lateral sclerosis |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2020-05-01 |
description |
We aimed to compare the sonographic measurement of median nerve cross-section area (CSA) in patients with Amyotrophic Lateral Sclerosis (ALS) and healthy individuals. The effect of duration of the disease on correlations between paraclinical findings and ALS functional rating scale (ALSFRS) were secondarily aimed to be evaluated. The cross-sectional study was approved by the Ethical Committee of Iran University of Medical Sciences and conducted between January 2017 and December 2018. We evaluated the median nerve surface area by means of sonography in 35 ALS patients and 35 healthy controls. Compound muscle action potential (CMAP) amplitudes during nerve conduction study and ALSFRS were recorded by the same trained specialist. Data were analyzed using SPSS software version 18. We did not find a significant difference between CSA in ALS patients and the normal population (P>0.05). Comparing to normal individuals, the mean CMAP decreased significantly in ALS patients (6.6±3.07 mV versus 10.25±2.2 mV, P<0.001). ALSFRS correlated with both CSA of the median nerve at the wrist (P:<0.001, r:0.78) and the CMAP (P:<0.001, r:0.74) that were confirmed by regression models designed to consider the effect of disease duration on these correlations. CSA was not different between ALS patients and the normal population, but CMAP decreased in ALS patients. ALSFRS correlated with both CSA and CMAP of the median nerve.
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topic |
Amyotrophic lateral sclerosis (ALS) Median nerve Cross-sectional area Compound muscle action potential (CMAP) ALS functional rating scale (ALSFRS) |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/8020 |
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