Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt

In sickle cell disease (SCD), prolonged capillary transit times, resulting from reduced peripheral blood flow, increase the likelihood of rigid red cells entrapment in the microvasculature, predisposing to vaso-occlusive crisis. Since changes in peripheral flow are mediated by the autonomic nervous...

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Bibliographic Details
Main Authors: Patjanaporn Chalacheva, Roberta M. Kato, Payal Shah, Saranya Veluswamy, Christopher C. Denton, John Sunwoo, Wanwara Thuptimdang, John C. Wood, Jon A. Detterich, Thomas D. Coates, Michael C. K. Khoo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
sickle cell anemia
autonomic dysfunction
orthostatic stress
phenotypic response
peripheral vasoconstriction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00381/full

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