Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia
The aim of the present study was to define the prevalence, characteristics, risk factors and impact on clinical outcomes of acute myocardial infarction (AMI) versus other cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). This was an international, multicentre, observa...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
European Respiratory Society
2015-09-01
|
Series: | ERJ Open Research |
Online Access: | http://openres.ersjournals.com/content/1/1/00020-2015.full |
id |
doaj-7adb06cdc98642cd8b99272d939acf06 |
---|---|
record_format |
Article |
spelling |
doaj-7adb06cdc98642cd8b99272d939acf062020-11-24T22:31:10ZengEuropean Respiratory SocietyERJ Open Research2312-05412015-09-011110.1183/23120541.00020-201500020-2015Acute myocardial infarction versus other cardiovascular events in community-acquired pneumoniaStefano Aliberti0Julio Ramirez1Roberto Cosentini2Vincenzo Valenti3Antonio Voza4Paolo Rossi5Daiana Stolz6Delfino Legnani7Alberto Pesci8Luca Richeldi9Paula Peyrani10Fernando Maria Massari11Francesco Blasi12 Health Science Department, University of Milan Bicocca, Respiratory Unit, AO San Gerardo, Monza, Italy Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY, USA Emergency Medicine Unit, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy Pulmonary Unit, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy Emergency Department, IRCCS Humanitas Research Hospital, Rozzano, Italy Internal Medicine Department, Azienda Ospedaliero-Universitaria “S. Maria della Misericordia”, Udine, Italy Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland Department of Biomedical and Clinical Sciences, University of Milan, Luigi Sacco Hospital, Milan, Italy Health Science Department, University of Milan Bicocca, Respiratory Unit, AO San Gerardo, Monza, Italy National Institute for Health Research Respiratory Biomedical Research Unit, Southampton, UK Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY, USA UOC Malattie Cardiovascolari, Università degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy Department of Pathophysiology and Transplantation, Università degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy The aim of the present study was to define the prevalence, characteristics, risk factors and impact on clinical outcomes of acute myocardial infarction (AMI) versus other cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). This was an international, multicentre, observational, prospective study of CAP patients hospitalised in eight hospitals in Italy and Switzerland. Three groups were identified: those without CVEs, those with AMI and those with other CVEs. Among 905 patients, 21 (2.3%) patients experienced at least one AMI, while 107 (11.7%) patients experienced at least one other CVE. Patients with CAP and either AMI or other CVEs showed a higher severity of the disease than patients with CAP alone. Female sex, liver disease and the presence of severe sepsis were independent predictors for the occurrence of AMI, while female sex, age >65 years, neurological disease and the presence of pleural effusion predicted other CVEs. In-hospital mortality was significantly higher among those who experienced AMI in comparison to those experiencing other CVEs (43% versus 21%, p=0.039). The presence of AMI showed an adjusted odds ratio for in-hospital mortality of 3.57 (p=0.012) and for other CVEs of 2.63 (p=0.002). These findings on AMI versus other CVEs as complications of CAP may be important when planning interventional studies on cardioprotective medications.http://openres.ersjournals.com/content/1/1/00020-2015.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefano Aliberti Julio Ramirez Roberto Cosentini Vincenzo Valenti Antonio Voza Paolo Rossi Daiana Stolz Delfino Legnani Alberto Pesci Luca Richeldi Paula Peyrani Fernando Maria Massari Francesco Blasi |
spellingShingle |
Stefano Aliberti Julio Ramirez Roberto Cosentini Vincenzo Valenti Antonio Voza Paolo Rossi Daiana Stolz Delfino Legnani Alberto Pesci Luca Richeldi Paula Peyrani Fernando Maria Massari Francesco Blasi Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia ERJ Open Research |
author_facet |
Stefano Aliberti Julio Ramirez Roberto Cosentini Vincenzo Valenti Antonio Voza Paolo Rossi Daiana Stolz Delfino Legnani Alberto Pesci Luca Richeldi Paula Peyrani Fernando Maria Massari Francesco Blasi |
author_sort |
Stefano Aliberti |
title |
Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia |
title_short |
Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia |
title_full |
Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia |
title_fullStr |
Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia |
title_full_unstemmed |
Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia |
title_sort |
acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia |
publisher |
European Respiratory Society |
series |
ERJ Open Research |
issn |
2312-0541 |
publishDate |
2015-09-01 |
description |
The aim of the present study was to define the prevalence, characteristics, risk factors and impact on clinical outcomes of acute myocardial infarction (AMI) versus other cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). This was an international, multicentre, observational, prospective study of CAP patients hospitalised in eight hospitals in Italy and Switzerland. Three groups were identified: those without CVEs, those with AMI and those with other CVEs. Among 905 patients, 21 (2.3%) patients experienced at least one AMI, while 107 (11.7%) patients experienced at least one other CVE. Patients with CAP and either AMI or other CVEs showed a higher severity of the disease than patients with CAP alone. Female sex, liver disease and the presence of severe sepsis were independent predictors for the occurrence of AMI, while female sex, age >65 years, neurological disease and the presence of pleural effusion predicted other CVEs. In-hospital mortality was significantly higher among those who experienced AMI in comparison to those experiencing other CVEs (43% versus 21%, p=0.039). The presence of AMI showed an adjusted odds ratio for in-hospital mortality of 3.57 (p=0.012) and for other CVEs of 2.63 (p=0.002). These findings on AMI versus other CVEs as complications of CAP may be important when planning interventional studies on cardioprotective medications. |
url |
http://openres.ersjournals.com/content/1/1/00020-2015.full |
work_keys_str_mv |
AT stefanoaliberti acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT julioramirez acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT robertocosentini acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT vincenzovalenti acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT antoniovoza acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT paolorossi acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT daianastolz acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT delfinolegnani acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT albertopesci acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT lucaricheldi acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT paulapeyrani acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT fernandomariamassari acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia AT francescoblasi acutemyocardialinfarctionversusothercardiovasculareventsincommunityacquiredpneumonia |
_version_ |
1725738315507826688 |