An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes
The utility of a universal reference sequence for human genome comparisons is dependent on the ethnic origins of the individuals being sequenced. Here the authors report a Korean reference genome and consensus variome, and show that an ethnically-relevant reference can improve variant detection.
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Nature Publishing Group
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13637 |
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doaj-7ade7dd90aad4501a7621d1dc5b2ed0a2021-05-11T11:16:09ZengNature Publishing GroupNature Communications2041-17232016-11-017111310.1038/ncomms13637An ethnically relevant consensus Korean reference genome is a step towards personal reference genomesYun Sung Cho0Hyunho Kim1Hak-Min Kim2Sungwoong Jho3JeHoon Jun4Yong Joo Lee5Kyun Shik Chae6Chang Geun Kim7Sangsoo Kim8Anders Eriksson9Jeremy S. Edwards10Semin Lee11Byung Chul Kim12Andrea Manica13Tae-Kwang Oh14George M. Church15Jong Bhak16The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)Geromics Inc., Ulsan National Institute of Science and Technology (UNIST)The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)Personal Genomics Institute, Genome Research FoundationPersonal Genomics Institute, Genome Research FoundationGeromics Inc., Ulsan National Institute of Science and Technology (UNIST)National Standard Reference Center, Korea Research Institute of Standards and ScienceNational Standard Reference Center, Korea Research Institute of Standards and ScienceSchool of Systems Biomedical Science, Soongsil UniversityDepartment of Zoology, University of CambridgeChemistry and Chemical Biology, UNM Comprehensive Cancer Center, University of New MexicoThe Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)The Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)Department of Zoology, University of CambridgeInfection and Immunity Research Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Genetics, New Research Building (NRB), Harvard Medical SchoolThe Genomics Institute (TGI), Ulsan National Institute of Science and Technology (UNIST)The utility of a universal reference sequence for human genome comparisons is dependent on the ethnic origins of the individuals being sequenced. Here the authors report a Korean reference genome and consensus variome, and show that an ethnically-relevant reference can improve variant detection.https://doi.org/10.1038/ncomms13637 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yun Sung Cho Hyunho Kim Hak-Min Kim Sungwoong Jho JeHoon Jun Yong Joo Lee Kyun Shik Chae Chang Geun Kim Sangsoo Kim Anders Eriksson Jeremy S. Edwards Semin Lee Byung Chul Kim Andrea Manica Tae-Kwang Oh George M. Church Jong Bhak |
| spellingShingle |
Yun Sung Cho Hyunho Kim Hak-Min Kim Sungwoong Jho JeHoon Jun Yong Joo Lee Kyun Shik Chae Chang Geun Kim Sangsoo Kim Anders Eriksson Jeremy S. Edwards Semin Lee Byung Chul Kim Andrea Manica Tae-Kwang Oh George M. Church Jong Bhak An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes Nature Communications |
| author_facet |
Yun Sung Cho Hyunho Kim Hak-Min Kim Sungwoong Jho JeHoon Jun Yong Joo Lee Kyun Shik Chae Chang Geun Kim Sangsoo Kim Anders Eriksson Jeremy S. Edwards Semin Lee Byung Chul Kim Andrea Manica Tae-Kwang Oh George M. Church Jong Bhak |
| author_sort |
Yun Sung Cho |
| title |
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes |
| title_short |
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes |
| title_full |
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes |
| title_fullStr |
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes |
| title_full_unstemmed |
An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes |
| title_sort |
ethnically relevant consensus korean reference genome is a step towards personal reference genomes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-11-01 |
| description |
The utility of a universal reference sequence for human genome comparisons is dependent on the ethnic origins of the individuals being sequenced. Here the authors report a Korean reference genome and consensus variome, and show that an ethnically-relevant reference can improve variant detection. |
| url |
https://doi.org/10.1038/ncomms13637 |
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