Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.

Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.

The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the desig...

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Main Authors: Lin Li, Shenghai Chang, Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang, Yingfang Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3427309?pdf=render
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spelling doaj-7aea93506e3a499bb4312b1a9a3cec382020-11-24T23:48:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e3523410.1371/journal.pone.0035234Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.Lin LiShenghai ChangJunfeng XiangQian LiHuanhuan LiangYalin TangYingfang LiuThe avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.http://europepmc.org/articles/PMC3427309?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Lin Li
Shenghai Chang
Junfeng Xiang
Qian Li
Huanhuan Liang
Yalin Tang
Yingfang Liu
spellingShingle Lin Li
Shenghai Chang
Junfeng Xiang
Qian Li
Huanhuan Liang
Yalin Tang
Yingfang Liu
Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
PLoS ONE
author_facet Lin Li
Shenghai Chang
Junfeng Xiang
Qian Li
Huanhuan Liang
Yalin Tang
Yingfang Liu
author_sort Lin Li
title Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
title_short Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
title_full Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
title_fullStr Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
title_full_unstemmed Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
title_sort screen anti-influenza lead compounds that target the pa(c) subunit of h5n1 viral rna polymerase.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2012-01-01
description The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
url http://europepmc.org/articles/PMC3427309?pdf=render
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AT shenghaichang screenantiinfluenzaleadcompoundsthattargetthepacsubunitofh5n1viralrnapolymerase
AT junfengxiang screenantiinfluenzaleadcompoundsthattargetthepacsubunitofh5n1viralrnapolymerase
AT qianli screenantiinfluenzaleadcompoundsthattargetthepacsubunitofh5n1viralrnapolymerase
AT huanhuanliang screenantiinfluenzaleadcompoundsthattargetthepacsubunitofh5n1viralrnapolymerase
AT yalintang screenantiinfluenzaleadcompoundsthattargetthepacsubunitofh5n1viralrnapolymerase
AT yingfangliu screenantiinfluenzaleadcompoundsthattargetthepacsubunitofh5n1viralrnapolymerase
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