A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs
Abstract Majority of drugs are administered orally, yet their efficient absorption is often difficult to achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill technology is reported with built‐in mixing capability for oral drug delivery that greatly enhances bi...
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doaj-7aec650ef0c143de98f57de489b4d0c72021-06-24T15:51:38ZengWileyAdvanced Science2198-38442021-06-01812n/an/a10.1002/advs.202100389A Microstirring Pill Enhances Bioavailability of Orally Administered DrugsRodolfo Mundaca‐Uribe0Emil Karshalev1Berta Esteban‐Fernández de Ávila2Xiaoli Wei3Bryan Nguyen4Irene Litvan5Ronnie H. Fang6Liangfang Zhang7Joseph Wang8Department of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Neurosciences University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USADepartment of Nanoengineering and Chemical Engineering Program University of California San Diego La Jolla CA 92093 USAAbstract Majority of drugs are administered orally, yet their efficient absorption is often difficult to achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill technology is reported with built‐in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. Embedding microscopic stirrers into a pill matrix enables faster disintegration and dissolution, leading to improved release profiles of three widely used model drugs, aspirin, levodopa, and acetaminophen, without compromising their loading. Unlike recently developed drug‐carrying nanomotors, drug molecules are not associated with the microstirrers, and hence there is no limitation on the loading capacity. These embedded microstirrers are fabricated through the asymmetric coating of titanium dioxide thin film onto magnesium microparticles. In vitro tests illustrate that the embedded microstirrers lead to substantial enhancement of local fluid transport. In vivo studies using murine and porcine models demonstrate that the localized stirring capability of microstirrers leads to enhanced bioavailability of drug payloads. Such improvements are of considerable importance in clinical scenarios where fast absorption and high bioavailability of therapeutics are critical. The encouraging results obtained in porcine model suggest that the microstirring pill technology has translational potential and can be developed toward practical biomedical applications.https://doi.org/10.1002/advs.202100389active drug deliverybioavailabilitymicrostirring pillsporcine modelstranslational medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rodolfo Mundaca‐Uribe Emil Karshalev Berta Esteban‐Fernández de Ávila Xiaoli Wei Bryan Nguyen Irene Litvan Ronnie H. Fang Liangfang Zhang Joseph Wang |
spellingShingle |
Rodolfo Mundaca‐Uribe Emil Karshalev Berta Esteban‐Fernández de Ávila Xiaoli Wei Bryan Nguyen Irene Litvan Ronnie H. Fang Liangfang Zhang Joseph Wang A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs Advanced Science active drug delivery bioavailability microstirring pills porcine models translational medicine |
author_facet |
Rodolfo Mundaca‐Uribe Emil Karshalev Berta Esteban‐Fernández de Ávila Xiaoli Wei Bryan Nguyen Irene Litvan Ronnie H. Fang Liangfang Zhang Joseph Wang |
author_sort |
Rodolfo Mundaca‐Uribe |
title |
A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs |
title_short |
A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs |
title_full |
A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs |
title_fullStr |
A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs |
title_full_unstemmed |
A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs |
title_sort |
microstirring pill enhances bioavailability of orally administered drugs |
publisher |
Wiley |
series |
Advanced Science |
issn |
2198-3844 |
publishDate |
2021-06-01 |
description |
Abstract Majority of drugs are administered orally, yet their efficient absorption is often difficult to achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill technology is reported with built‐in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. Embedding microscopic stirrers into a pill matrix enables faster disintegration and dissolution, leading to improved release profiles of three widely used model drugs, aspirin, levodopa, and acetaminophen, without compromising their loading. Unlike recently developed drug‐carrying nanomotors, drug molecules are not associated with the microstirrers, and hence there is no limitation on the loading capacity. These embedded microstirrers are fabricated through the asymmetric coating of titanium dioxide thin film onto magnesium microparticles. In vitro tests illustrate that the embedded microstirrers lead to substantial enhancement of local fluid transport. In vivo studies using murine and porcine models demonstrate that the localized stirring capability of microstirrers leads to enhanced bioavailability of drug payloads. Such improvements are of considerable importance in clinical scenarios where fast absorption and high bioavailability of therapeutics are critical. The encouraging results obtained in porcine model suggest that the microstirring pill technology has translational potential and can be developed toward practical biomedical applications. |
topic |
active drug delivery bioavailability microstirring pills porcine models translational medicine |
url |
https://doi.org/10.1002/advs.202100389 |
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