Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts

Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts

Extracellular matrix mineralization is critical for osteogenesis, and its dysregulation could result in osteoporosis and vascular calcification. IKK/NF-κB activation inhibits differentiation of osteoblasts, and reduces extracellular matrix mineralization, however the underlying mechanisms are poorly...

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Bibliographic Details
Main Authors: Qianyun Hao, Zhuangzhuang Liu, Liaoxun Lu, Lichen Zhang, Li Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Endocrinology
Subjects:
osteoblasts
IKKβ
NF-κB
JNK1
JNK2
CRISPR/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00013/full

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