Recapitulating the Vasculature Using Organ-On-Chip Technology

The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the...

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Main Authors:	Andreas M.A.O. Pollet, Jaap M.J. den Toonder
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Bioengineering
Subjects:	vasculature organ-on-chip microfabrication microfluidics angiogenesis vasculogenesis
Online Access:	https://www.mdpi.com/2306-5354/7/1/17

id	doaj-7af911115ac949b789882b1d272946a3
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spelling	doaj-7af911115ac949b789882b1d272946a32020-11-25T00:36:20ZengMDPI AGBioengineering2306-53542020-02-01711710.3390/bioengineering7010017bioengineering7010017Recapitulating the Vasculature Using Organ-On-Chip TechnologyAndreas M.A.O. Pollet0Jaap M.J. den Toonder1Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The NetherlandsMicrosystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The NetherlandsThe development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the capability of recapitulating the in vivo vasculature differs greatly between them. The first part of this review discusses the biological background of the in vivo vasculature and all the associated processes. We then evaluate the biological relevance of different fabrication methods proposed for Vasculature-on-Chip, we indicate their possibilities and limitations, and we assess which fabrication methods are capable of recapitulating the intrinsic complexity of the vasculature. This review illustrates the complexity involved in developing in vitro vasculature and provides an overview of fabrication methods for Vasculature-on-Chip in relation to the biological relevance of such methods.https://www.mdpi.com/2306-5354/7/1/17vasculatureorgan-on-chipmicrofabricationmicrofluidicsangiogenesisvasculogenesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andreas M.A.O. Pollet Jaap M.J. den Toonder
spellingShingle	Andreas M.A.O. Pollet Jaap M.J. den Toonder Recapitulating the Vasculature Using Organ-On-Chip Technology Bioengineering vasculature organ-on-chip microfabrication microfluidics angiogenesis vasculogenesis
author_facet	Andreas M.A.O. Pollet Jaap M.J. den Toonder
author_sort	Andreas M.A.O. Pollet
title	Recapitulating the Vasculature Using Organ-On-Chip Technology
title_short	Recapitulating the Vasculature Using Organ-On-Chip Technology
title_full	Recapitulating the Vasculature Using Organ-On-Chip Technology
title_fullStr	Recapitulating the Vasculature Using Organ-On-Chip Technology
title_full_unstemmed	Recapitulating the Vasculature Using Organ-On-Chip Technology
title_sort	recapitulating the vasculature using organ-on-chip technology
publisher	MDPI AG
series	Bioengineering
issn	2306-5354
publishDate	2020-02-01
description	The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the capability of recapitulating the in vivo vasculature differs greatly between them. The first part of this review discusses the biological background of the in vivo vasculature and all the associated processes. We then evaluate the biological relevance of different fabrication methods proposed for Vasculature-on-Chip, we indicate their possibilities and limitations, and we assess which fabrication methods are capable of recapitulating the intrinsic complexity of the vasculature. This review illustrates the complexity involved in developing in vitro vasculature and provides an overview of fabrication methods for Vasculature-on-Chip in relation to the biological relevance of such methods.
topic	vasculature organ-on-chip microfabrication microfluidics angiogenesis vasculogenesis
url	https://www.mdpi.com/2306-5354/7/1/17
work_keys_str_mv	AT andreasmaopollet recapitulatingthevasculatureusingorganonchiptechnology AT jaapmjdentoonder recapitulatingthevasculatureusingorganonchiptechnology
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Recapitulating the Vasculature Using Organ-On-Chip Technology

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