Distinct EpCAM-Positive Stem Cell Niches Are Engaged in Chronic and Neoplastic Liver Diseases

Distinct EpCAM-Positive Stem Cell Niches Are Engaged in Chronic and Neoplastic Liver Diseases

In normal human livers, EpCAMpos cells are mostly restricted in two distinct niches, which are (i) the bile ductules and (ii) the mucous glands present inside the wall of large intrahepatic bile ducts (the so-called peribiliary glands). These EpCAMpos cell niches have been proven to harbor stem/prog...

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Bibliographic Details
Main Authors: Samira Safarikia, Guido Carpino, Diletta Overi, Vincenzo Cardinale, Rosanna Venere, Antonio Franchitto, Paolo Onori, Domenico Alvaro, Eugenio Gaudio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Medicine
Subjects:
progenitor cells
liver
biliary tree
cholangiopathy
cholangiocarcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00479/full

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