Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization

Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization

Alzheimer’s disease is the leading cause of dementia in the elderly. Pathologically it is characterized by the presence of amyloid plaques and neuronal loss within the brain tissue of affected individuals. It is now widely hypothesised that fibrillar structures represent an inert structure. Biophysi...

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Bibliographic Details
Main Authors: Timothy M. Ryan, Joanne Caine, Haydyn D.T. Mertens, Nigel Kirby, Julie Nigro, Kerry Breheney, Lynne J. Waddington, Victor A. Streltsov, Cyril Curtain, Colin L. Masters, Blaine R. Roberts
Format: Article
Language:English
Published: PeerJ Inc. 2013-05-01
Series:PeerJ
Subjects:
Amyloid
Hexafluoroisopropanol
Ammonium Hydroxide
Aggregation
A β
A β toxicity
Online Access:https://peerj.com/articles/73.pdf

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