CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting

CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting

Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view. Their activity can be measured by phenotyping, and/or predicted by...

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Bibliographic Details
Main Authors: Kuntheavy Ing Lorenzini, Jules Desmeules, Victoria Rollason, Stéphane Bertin, Marie Besson, Youssef Daali, Caroline F. Samer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
cytochromes P450
phenotype
genotype
phenoconversion
drug-drug interaction
inefficacy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.730637/full

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