Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab
Radiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivol...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/56/4/155 |
| id |
doaj-7b277097699e434ea3528901d5bc4151 |
|---|---|
| record_format |
Article |
| spelling |
doaj-7b277097699e434ea3528901d5bc41512020-11-25T02:05:23ZengMDPI AGMedicina1010-660X2020-03-015615515510.3390/medicina56040155Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with NivolumabLukas Šalaševičius0Goda Elizabeta Vaitkevičienė1Ramunė Pasaulienė2Rosita Kiudelienė3Ernesta Ivanauskaitė-Didžiokienė4Donatas Vajauskas5Nemira Jurkienė6Jelena Rascon7Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaCenter for Pediatric Oncology and Hematology, Vilnius University, 08406 Vilnius, LithuaniaCenter of Pediatric Oncology and Hematology at Pediatric Department and Hospital of Kauno Klinikos, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaNational Center of Pathology, 08406 Vilnius, LithuaniaInstitute of Biomedical Sciences, Department of Radiology, Nuclear Medicine and Medical Physics, Vilnius University, 03101 Vilnius, LithuanianRadiology Clinic, Nuclear Medicine Department of Kauno Klinikos, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaRadiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment.https://www.mdpi.com/1010-660X/56/4/155Hodgkin lymphomapost-radiation sarcomaNivolumabchildrenobesity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lukas Šalaševičius Goda Elizabeta Vaitkevičienė Ramunė Pasaulienė Rosita Kiudelienė Ernesta Ivanauskaitė-Didžiokienė Donatas Vajauskas Nemira Jurkienė Jelena Rascon |
| spellingShingle |
Lukas Šalaševičius Goda Elizabeta Vaitkevičienė Ramunė Pasaulienė Rosita Kiudelienė Ernesta Ivanauskaitė-Didžiokienė Donatas Vajauskas Nemira Jurkienė Jelena Rascon Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab Medicina Hodgkin lymphoma post-radiation sarcoma Nivolumab children obesity |
| author_facet |
Lukas Šalaševičius Goda Elizabeta Vaitkevičienė Ramunė Pasaulienė Rosita Kiudelienė Ernesta Ivanauskaitė-Didžiokienė Donatas Vajauskas Nemira Jurkienė Jelena Rascon |
| author_sort |
Lukas Šalaševičius |
| title |
Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab |
| title_short |
Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab |
| title_full |
Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab |
| title_fullStr |
Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab |
| title_full_unstemmed |
Early Radiation-Induced Sarcoma in an Adolescent Treated for Relapsed Hodgkin Lymphoma with Nivolumab |
| title_sort |
early radiation-induced sarcoma in an adolescent treated for relapsed hodgkin lymphoma with nivolumab |
| publisher |
MDPI AG |
| series |
Medicina |
| issn |
1010-660X |
| publishDate |
2020-03-01 |
| description |
Radiation-induced sarcoma (RIS) has been reported as a late secondary malignancy following radiotherapy for various types of cancer with a median latency of 10 years. We describe an early RIS that developed in an adolescent within three years of treatment (including PD-L1 check-point inhibitor Nivolumab) of a relapsed classic Hodgkin lymphoma (HL) and was diagnosed post-mortem. The patient died of the progressive RIS that was misleadingly assumed to be a resistant HL based on the positive PET/CT scan. Repetitive tumor biopsies are warranted in cases of aggressive and multi-drug resistant HL to validate imaging findings, ensure correct diagnosis and avoid overtreatment. |
| topic |
Hodgkin lymphoma post-radiation sarcoma Nivolumab children obesity |
| url |
https://www.mdpi.com/1010-660X/56/4/155 |
| work_keys_str_mv |
AT lukassalasevicius earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT godaelizabetavaitkeviciene earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT ramunepasauliene earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT rositakiudeliene earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT ernestaivanauskaitedidziokiene earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT donatasvajauskas earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT nemirajurkiene earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab AT jelenarascon earlyradiationinducedsarcomainanadolescenttreatedforrelapsedhodgkinlymphomawithnivolumab |
| _version_ |
1724938365118185472 |