Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death

Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death

Background: Survival and evolution of aneuploid cells after an asymmetric segregation of chromosomes at mitosis may be the common initiating event and underlying cause of the genetic diversity and adaptability of cancers. We hypothesize that mechanisms exist to detect impending aneuploidy and preven...

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Main Authors: Leyuan Liu, Rui Xie, Chaofeng Yang, Wallace L. McKeehan
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2009-0484
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spelling doaj-7b2e888a89154c30ba5d12e037c4a2aa2020-11-24T22:25:59ZengHindawi LimitedCellular Oncology1570-58701875-86062009-01-0131539340510.3233/CLO-2009-0484Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell DeathLeyuan Liu0Rui Xie1Chaofeng Yang2Wallace L. McKeehan3Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USACenter for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USACenter for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USACenter for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USABackground: Survival and evolution of aneuploid cells after an asymmetric segregation of chromosomes at mitosis may be the common initiating event and underlying cause of the genetic diversity and adaptability of cancers. We hypothesize that mechanisms exist to detect impending aneuploidy and prevent it before completion of an aberrant mitosis.http://dx.doi.org/10.3233/CLO-2009-0484
collection DOAJ
language English
format Article
sources DOAJ
author Leyuan Liu
Rui Xie
Chaofeng Yang
Wallace L. McKeehan
spellingShingle Leyuan Liu
Rui Xie
Chaofeng Yang
Wallace L. McKeehan
Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death
Cellular Oncology
author_facet Leyuan Liu
Rui Xie
Chaofeng Yang
Wallace L. McKeehan
author_sort Leyuan Liu
title Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death
title_short Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death
title_full Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death
title_fullStr Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death
title_full_unstemmed Dual Function Microtubule- and Mitochondria-Associated Proteins Mediate Mitotic Cell Death
title_sort dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death
publisher Hindawi Limited
series Cellular Oncology
issn 1570-5870
1875-8606
publishDate 2009-01-01
description Background: Survival and evolution of aneuploid cells after an asymmetric segregation of chromosomes at mitosis may be the common initiating event and underlying cause of the genetic diversity and adaptability of cancers. We hypothesize that mechanisms exist to detect impending aneuploidy and prevent it before completion of an aberrant mitosis.
url http://dx.doi.org/10.3233/CLO-2009-0484
work_keys_str_mv AT leyuanliu dualfunctionmicrotubuleandmitochondriaassociatedproteinsmediatemitoticcelldeath
AT ruixie dualfunctionmicrotubuleandmitochondriaassociatedproteinsmediatemitoticcelldeath
AT chaofengyang dualfunctionmicrotubuleandmitochondriaassociatedproteinsmediatemitoticcelldeath
AT wallacelmckeehan dualfunctionmicrotubuleandmitochondriaassociatedproteinsmediatemitoticcelldeath
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