Obstructive sleep apnea and the severity of coronary artery disease

• Main Authors: Ali Vasheghani-Farahani, Fatemeh Kazemnejad, Khosro Sadeghniiat-Haghighi, Soleil Saadat, Parya Tavakoli poor, Tahereh Yazdani, Mohammad Alidoosti, Vahid Ghasem Amooeian, Haleh Ashraf
• Format: Article
• Language: English
• Published: Babol University of Medical Sciences 2018-05-01
• Series: Caspian Journal of Internal Medicine
• Subjects: Atherosclerosis; coronary angiography; coronary artery disease; Gensini score; Obstructive sleep apnea
• Online Access: http://caspjim.com/browse.php?a_code=A-10-755-2&slc_lang=en&sid=1
• ISSN: 2008-6164; 2008-6172

Background: It has been implicated that obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular disease including stroke, myocardial infarction, coronary artery disease (CAD) and hypertension. The aim of this study was to investigate the correlation between OSA and severity of atherosclerosis assessed by angiography. Methods: This study included 337 patients undergoing diagnostic coronary angiography at Tehran Heart Center, Iran. The Gensini score was obtained from each patient for coronary angiogram, and OSA were assessed by using Multivariable apnea prediction (MAP) risk index on the day of cardiac catheterization. The Gensini scores increased in accordance with increases in the MAP value. Results: The prevalence rates of three-vessel disease were 68.0% in OSA group and 32.0% in non-OSA group. The MAP index was the most significant independent determinant for the Gensini score. Conclusions: The independent association between OSA and CAD, even after adjustment for traditional confounders, suggests that, OSA should be taken into account when considering risk factors for CAD.