Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota

Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota

Abstract Background Chaihu-Shugan-San (CSS, named Shihosogansan in Korean), a Chinese traditional medicine, is frequently used to treat anxiety and depression. Psychiatric disorders including depression are associated with gut dysbiosis. Therefore, to comprehend gut microbiota-involved anti-depressi...

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Bibliographic Details
Main Authors: Sang-Kap Han, Jeon-Kyung Kim, Hee-Seo Park, Yeun-Jeong Shin, Dong-Hyun Kim
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Chinese Medicine
Subjects:
Chaihu-Shugan-San
Depression
Fecal microbiota transplantation
Gut microbiota
Online Access:https://doi.org/10.1186/s13020-021-00492-5

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