Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a s...
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American Society for Microbiology
2020-07-01
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Online Access: | https://doi.org/10.1128/mBio.01175-20 |
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doaj-7b58ad79b153472bbaabb82529d6a86f2021-07-02T15:21:29ZengAmerican Society for MicrobiologymBio2150-75112020-07-01114e01175-2010.1128/mBio.01175-20Pathogenesis of COVID-19 from the Perspective of the Damage-Response FrameworkLiise-anne PirofskiArturo CasadevallThe coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease.The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease.https://doi.org/10.1128/mBio.01175-20covidviral pathogenesisvirus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liise-anne Pirofski Arturo Casadevall |
spellingShingle |
Liise-anne Pirofski Arturo Casadevall Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework mBio covid viral pathogenesis virus |
author_facet |
Liise-anne Pirofski Arturo Casadevall |
author_sort |
Liise-anne Pirofski |
title |
Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework |
title_short |
Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework |
title_full |
Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework |
title_fullStr |
Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework |
title_full_unstemmed |
Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework |
title_sort |
pathogenesis of covid-19 from the perspective of the damage-response framework |
publisher |
American Society for Microbiology |
series |
mBio |
issn |
2150-7511 |
publishDate |
2020-07-01 |
description |
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease.The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease. |
topic |
covid viral pathogenesis virus |
url |
https://doi.org/10.1128/mBio.01175-20 |
work_keys_str_mv |
AT liiseannepirofski pathogenesisofcovid19fromtheperspectiveofthedamageresponseframework AT arturocasadevall pathogenesisofcovid19fromtheperspectiveofthedamageresponseframework |
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1721327240385396736 |