Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.

Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.

Strains of simian immunodeficiency virus (SIV) that are limited to a single cycle of infection were evaluated for the ability to elicit protective immunity against wild-type SIV(mac)239 infection of rhesus macaques by two different vaccine regimens. Six animals were inoculated at 8-week intervals wi...

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Bibliographic Details
Main Authors: Bin Jia, Sharon K Ng, M Quinn DeGottardi, Michael Piatak, Eloísa Yuste, Angela Carville, Keith G Mansfield, Wenjun Li, Barbra A Richardson, Jeffrey D Lifson, David T Evans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2621341?pdf=render

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