A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas

A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas

Summary: We applied digital spatial profiling for 87 immune and stromal genes to lymph node germinal center (GC) dark- and light-zone (DZ/LZ) regions of interest to obtain a differential signature of these two distinct microenvironments. The spatially resolved 53-genes signature, comprising key gene...

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Bibliographic Details
Main Authors: Claudio Tripodo, Federica Zanardi, Fabio Iannelli, Saveria Mazzara, Mariella Vegliante, Gaia Morello, Arianna Di Napoli, Alessandro Mangogna, Fabio Facchetti, Sabina Sangaletti, Claudia Chiodoni, Alison VanShoiack, Anand D. Jeyasekharan, Stefano Casola, Mario P. Colombo, Maurilio Ponzoni, Stefano A. Pileri
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Cancer Systems Biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307549

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