Exploring induced pluripotency in human fibroblasts via construction, validation, and application of a gene regulatory network.

Reprogramming of somatic cells to induced pluripotent stem cells, by overexpressing certain factors referred to as the reprogramming factors, can revolutionize regenerative medicine. To provide a coherent description of induced pluripotency from the gene regulation perspective, we use 35 microarray...

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Bibliographic Details
Main Authors: Mehdi B Hamaneh, Yi-Kuo Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0220742

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