β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive
Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated...
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doaj-7b6e570b956b446d8b43736d35277ee32021-01-13T00:05:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-012270070010.3390/ijms22020700β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-AdhesiveYoung Jae Moon0Sun-Jung Yoon1Jeung-Hyun Koo2Yihyun Yoon3Hye Jun Byun4Hyeon Soo Kim5Gilson Khang6Heung Jae Chun7Dae Hyeok Yang8Department of Biochemistry & Molecular Biology & Orthopaedic Surgery, Research Institute for Endocrine Sciences, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju 54896, KoreaDepartment of Orthopedic Surgery, Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju 54896, KoreaDepartment of Biochemistry & Molecular Biology & Orthopaedic Surgery, Research Institute for Endocrine Sciences, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju 54896, KoreaInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of BIN Convergence Technology & Polymer Nano Science & Technology and Polymer BIN Research Center, Jeonbuk National University, Jeonju 54896, KoreaInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaAccelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (<sup>1</sup>H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.https://www.mdpi.com/1422-0067/22/2/700methacrylate glycol chitosanbeta-cyclodextrintriclosanantibacterialtissue bio-adhesive |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Young Jae Moon Sun-Jung Yoon Jeung-Hyun Koo Yihyun Yoon Hye Jun Byun Hyeon Soo Kim Gilson Khang Heung Jae Chun Dae Hyeok Yang |
spellingShingle |
Young Jae Moon Sun-Jung Yoon Jeung-Hyun Koo Yihyun Yoon Hye Jun Byun Hyeon Soo Kim Gilson Khang Heung Jae Chun Dae Hyeok Yang β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive International Journal of Molecular Sciences methacrylate glycol chitosan beta-cyclodextrin triclosan antibacterial tissue bio-adhesive |
author_facet |
Young Jae Moon Sun-Jung Yoon Jeung-Hyun Koo Yihyun Yoon Hye Jun Byun Hyeon Soo Kim Gilson Khang Heung Jae Chun Dae Hyeok Yang |
author_sort |
Young Jae Moon |
title |
β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive |
title_short |
β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive |
title_full |
β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive |
title_fullStr |
β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive |
title_full_unstemmed |
β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive |
title_sort |
β-cyclodextrin/triclosan complex-grafted methacrylated glycol chitosan hydorgel by photocrosslinking via visible light irradiation for a tissue bio-adhesive |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-01-01 |
description |
Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (<sup>1</sup>H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive. |
topic |
methacrylate glycol chitosan beta-cyclodextrin triclosan antibacterial tissue bio-adhesive |
url |
https://www.mdpi.com/1422-0067/22/2/700 |
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