Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies
AIM: To evaluate the structural injure patterns in peripapillary retinal fiber layer (pRNFL), retinal ganglion cell layer (RGCL) and their correlations to visual function in various mitochondrial optic neuropathies (MON) to offer help to their differential diagnosis. METHODS: Totally 32 MON patient...
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doaj-7b7fb6890ae74cf4af56e612492d4a902020-11-25T00:07:14ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982018-10-0111101643164810.18240/ijo.2018.10.11Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathiesDa Teng0Chun-Xia Peng1Hai-Yan Qian2Li Li3Wei Wang4Jun-Qing Wang5Bing Chen6Huan-Fen Zhou7Shi-Hui Wei8Ophthalmology Department, Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, ChinaOphthalmology Department, Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, ChinaZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, ChinaOphthalmology Department, Chinese PLA General Hospital, Beijing 100853, ChinaOphthalmology Department, Chinese PLA General Hospital, Beijing 100853, ChinaOphthalmology Department, Chinese PLA General Hospital, Beijing 100853, ChinaOphthalmology Department, Chinese PLA General Hospital, Beijing 100853, ChinaAIM: To evaluate the structural injure patterns in peripapillary retinal fiber layer (pRNFL), retinal ganglion cell layer (RGCL) and their correlations to visual function in various mitochondrial optic neuropathies (MON) to offer help to their differential diagnosis. METHODS: Totally 32 MON patients (60 eyes) were recruited within 6mo after clinical onsets, including 20 Leber hereditary optic neuropathy (LHON) patients (37 eyes), 12 ethambutol-induced optic neuropathy (EON) patients (23 eyes), and 41 age-gender matched healthy controls (HC, 82 eyes). All subjects had pRNFL and RGCL examinations with optic coherence tomography (OCT) and visual function tests. RESULTS: In the early stages of MON, the temporal pRNFL thickness decreased (66.09±22.57 μm), but increased in other quadrants, compared to HC (76.95±14.81 μm). The other quadrants remaining stable for LHON and EON patients besides the second hour sector of pRNFL thickness reduced and the temporal pRNFL decreased (56.78±15.87 μm) for EON. Total macular thickness in MON reduced remarkably (279.25±18.90 μm; P=0.015), which mainly occurring in the inner circle (3 mm diameter of circle) and the nasal temporal sectors in the outer circle (5.5 mm diameter of circle), in contrast to those in HC. RGCL thickness reduced in each sector of the macula (61.90±8.73 μm; P≤0.001). It strongly showed the correlationship of best corrected visual acuity (R=0.50, P=0.0003) and visual field injury (R=0.54, P=0.0002) in MON patients. CONCLUSION: OCT is a potential tool for detecting structural alterations in the optic nerves of various MON. Different types of MON may have different damage patterns.http://www.ijo.cn/en_publish/2018/10/20181011.pdfmitochondrial optic neuropathiesperipapillary retinal fiber layerretinal ganglion cell layervisual functionLeber hereditary optic neuropathyethambutol-induced optic neuropathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Da Teng Chun-Xia Peng Hai-Yan Qian Li Li Wei Wang Jun-Qing Wang Bing Chen Huan-Fen Zhou Shi-Hui Wei |
spellingShingle |
Da Teng Chun-Xia Peng Hai-Yan Qian Li Li Wei Wang Jun-Qing Wang Bing Chen Huan-Fen Zhou Shi-Hui Wei Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies International Journal of Ophthalmology mitochondrial optic neuropathies peripapillary retinal fiber layer retinal ganglion cell layer visual function Leber hereditary optic neuropathy ethambutol-induced optic neuropathy |
author_facet |
Da Teng Chun-Xia Peng Hai-Yan Qian Li Li Wei Wang Jun-Qing Wang Bing Chen Huan-Fen Zhou Shi-Hui Wei |
author_sort |
Da Teng |
title |
Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies |
title_short |
Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies |
title_full |
Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies |
title_fullStr |
Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies |
title_full_unstemmed |
Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies |
title_sort |
structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2018-10-01 |
description |
AIM: To evaluate the structural injure patterns in peripapillary retinal fiber layer (pRNFL), retinal ganglion cell layer (RGCL) and their correlations to visual function in various mitochondrial optic neuropathies (MON) to offer help to their differential diagnosis.
METHODS: Totally 32 MON patients (60 eyes) were recruited within 6mo after clinical onsets, including 20 Leber hereditary optic neuropathy (LHON) patients (37 eyes), 12 ethambutol-induced optic neuropathy (EON) patients (23 eyes), and 41 age-gender matched healthy controls (HC, 82 eyes). All subjects had pRNFL and RGCL examinations with optic coherence tomography (OCT) and visual function tests.
RESULTS: In the early stages of MON, the temporal pRNFL thickness decreased (66.09±22.57 μm), but increased in other quadrants, compared to HC (76.95±14.81 μm). The other quadrants remaining stable for LHON and EON patients besides the second hour sector of pRNFL thickness reduced and the temporal pRNFL decreased (56.78±15.87 μm) for EON. Total macular thickness in MON reduced remarkably (279.25±18.90 μm; P=0.015), which mainly occurring in the inner circle (3 mm diameter of circle) and the nasal temporal sectors in the outer circle (5.5 mm diameter of circle), in contrast to those in HC. RGCL thickness reduced in each sector of the macula (61.90±8.73 μm; P≤0.001). It strongly showed the correlationship of best corrected visual acuity (R=0.50, P=0.0003) and visual field injury (R=0.54, P=0.0002) in MON patients.
CONCLUSION: OCT is a potential tool for detecting structural alterations in the optic nerves of various MON. Different types of MON may have different damage patterns. |
topic |
mitochondrial optic neuropathies peripapillary retinal fiber layer retinal ganglion cell layer visual function Leber hereditary optic neuropathy ethambutol-induced optic neuropathy |
url |
http://www.ijo.cn/en_publish/2018/10/20181011.pdf |
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