Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.

Bibliographic Details
Main Authors:	Nathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn. J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk, Katherine L. Wright, Rita M. Quintana, Yeji An, Daniel Dotzko, Jennifer L. Gorman, Daria Wojtal, Juhi S. Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J. Dupuy, Charles M. Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R. Woodgett, Susan J. Done, Livia Garzia, A. Sorana Morrissy, Jüri Reimand, Michael D. Taylor, Sean E. Egan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25467-w

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spelling	doaj-7b80ad2dd67744ecb57557946c051bff2021-09-05T11:44:04ZengNature Publishing GroupNature Communications2041-17232021-09-0112111910.1038/s41467-021-25467-wSingle allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancerNathan F. Schachter0Jessica R. Adams1Patryk Skowron2Katelyn. J. Kozma3Christian A. Lee4Nandini Raghuram5Joanna Yang6Amanda J. Loch7Wei Wang8Aaron Kucharczuk9Katherine L. Wright10Rita M. Quintana11Yeji An12Daniel Dotzko13Jennifer L. Gorman14Daria Wojtal15Juhi S. Shah16Paul Leon-Gomez17Giovanna Pellecchia18Adam J. Dupuy19Charles M. Perou20Ittai Ben-Porath21Rotem Karni22Eldad Zacksenhaus23Jim R. Woodgett24Susan J. Done25Livia Garzia26A. Sorana Morrissy27Jüri Reimand28Michael D. Taylor29Sean E. Egan30Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Developmental & Stem Cell Biology, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenComputational Biology Program, Ontario Institute for Cancer ResearchProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenLunenfeld-Tanenbaum Research Institute, Sinai Health SystemDepartment of Molecular Genetics, University of TorontoProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenThe Center for Applied Genomics, The Hospital for Sick ChildrenDepartment of Pathology, Carver College of Medicine, The University of IowaLineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North CarolinaDepartment of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical SchoolDepartment of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical SchoolDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Medical Biophysics, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoProgram in Developmental & Stem Cell Biology, The Hospital for Sick ChildrenProgram in Developmental & Stem Cell Biology, The Hospital for Sick ChildrenDepartment of Molecular Genetics, University of TorontoProgram in Developmental & Stem Cell Biology, The Hospital for Sick ChildrenProgram in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick ChildrenTransposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.https://doi.org/10.1038/s41467-021-25467-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nathan F. Schachter Jessica R. Adams Patryk Skowron Katelyn. J. Kozma Christian A. Lee Nandini Raghuram Joanna Yang Amanda J. Loch Wei Wang Aaron Kucharczuk Katherine L. Wright Rita M. Quintana Yeji An Daniel Dotzko Jennifer L. Gorman Daria Wojtal Juhi S. Shah Paul Leon-Gomez Giovanna Pellecchia Adam J. Dupuy Charles M. Perou Ittai Ben-Porath Rotem Karni Eldad Zacksenhaus Jim R. Woodgett Susan J. Done Livia Garzia A. Sorana Morrissy Jüri Reimand Michael D. Taylor Sean E. Egan
spellingShingle	Nathan F. Schachter Jessica R. Adams Patryk Skowron Katelyn. J. Kozma Christian A. Lee Nandini Raghuram Joanna Yang Amanda J. Loch Wei Wang Aaron Kucharczuk Katherine L. Wright Rita M. Quintana Yeji An Daniel Dotzko Jennifer L. Gorman Daria Wojtal Juhi S. Shah Paul Leon-Gomez Giovanna Pellecchia Adam J. Dupuy Charles M. Perou Ittai Ben-Porath Rotem Karni Eldad Zacksenhaus Jim R. Woodgett Susan J. Done Livia Garzia A. Sorana Morrissy Jüri Reimand Michael D. Taylor Sean E. Egan Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer Nature Communications
author_facet	Nathan F. Schachter Jessica R. Adams Patryk Skowron Katelyn. J. Kozma Christian A. Lee Nandini Raghuram Joanna Yang Amanda J. Loch Wei Wang Aaron Kucharczuk Katherine L. Wright Rita M. Quintana Yeji An Daniel Dotzko Jennifer L. Gorman Daria Wojtal Juhi S. Shah Paul Leon-Gomez Giovanna Pellecchia Adam J. Dupuy Charles M. Perou Ittai Ben-Porath Rotem Karni Eldad Zacksenhaus Jim R. Woodgett Susan J. Done Livia Garzia A. Sorana Morrissy Jüri Reimand Michael D. Taylor Sean E. Egan
author_sort	Nathan F. Schachter
title	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_short	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_full	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_fullStr	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_full_unstemmed	Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
title_sort	single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection for common chromosome arm losses in cancer.
url	https://doi.org/10.1038/s41467-021-25467-w
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Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

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