Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital
Abstract Purpose To quantify incidental thyroid pathology including malignancy on routine 18F-FDG PET-CT scans To compare standardised uptake values (SUVmax) in thyroid malignancy subtypes Methods and materials This is a retrospective study of all 18F-FDG PET-CT scans (n = 6179) performed in a teach...
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doaj-7b8c7d0b4f0140e09453b5128e51f8582020-11-25T04:09:53ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362020-11-01411810.1186/s41824-020-00089-5Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospitalShea Roddy0Thomas Biggans1Ahmad K. Raofi2Avinash Kanodia3Thiru Sudarshan4Prasad Guntur Ramkumar5Department of Radiology, Ninewells HospitalDepartment of Nuclear Medicine, Ninewells HospitalDepartment of Radiology, Ninewells HospitalDepartment of Radiology, Ninewells HospitalDepartment of Radiology, Ninewells HospitalDepartment of Radiology, Ninewells HospitalAbstract Purpose To quantify incidental thyroid pathology including malignancy on routine 18F-FDG PET-CT scans To compare standardised uptake values (SUVmax) in thyroid malignancy subtypes Methods and materials This is a retrospective study of all 18F-FDG PET-CT scans (n = 6179) performed in a teaching hospital between June 2010 and May 2019. RIS database search of reports for the word “thyroid” was performed. Studies with evidence of thyroid uptake were included. Patient age and gender, primary indication for PET scan (malignant or non-malignant), thyroid result on PET (diffuse or focal tracer uptake, SUVmax), ultrasound and FNAC results were recorded. Results Incidental abnormal thyroid tracer uptake as a proportion of all 18F-FDG PET-CT scans was 4.37% (n = 270). Out of region patients (n = 87) whose records could not be obtained were excluded leaving a study group of n = 183. Ninety-four in this group had focal uptake, and 89 had diffuse uptake. Fifty-five patients in the focal group had undergone further investigations. Of these, 30 were thought to be benign on USS alone, and 25 patients underwent USS/FNAC. Thirteen (24%) malignancies were identified (5 papillary, 6 follicular, 1 poorly differentiated thyroid cancer, 1 metastatic malignancy). Mean SUVmax for papillary carcinoma was noted to be 8.2 g/ml, and follicular carcinoma was 12.6 g/ml. Conclusion Incidental abnormal thyroid 18F-FDG PET-CT uptake in PET-CT scans of 4.37% is in keeping with the known limited literature. Rather similar number of patients was noted in the focal and diffuse tracer uptake categories in the final study group. Around quarter of the focal lesions were identified to be malignant, implying focal lesions should always be further investigated.http://link.springer.com/article/10.1186/s41824-020-00089-5Thyroid malignancyHybrid imagingPositron emission tomography computed tomography18-FluorodeoxyglucoseStandardised uptake value |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shea Roddy Thomas Biggans Ahmad K. Raofi Avinash Kanodia Thiru Sudarshan Prasad Guntur Ramkumar |
spellingShingle |
Shea Roddy Thomas Biggans Ahmad K. Raofi Avinash Kanodia Thiru Sudarshan Prasad Guntur Ramkumar Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital European Journal of Hybrid Imaging Thyroid malignancy Hybrid imaging Positron emission tomography computed tomography 18-Fluorodeoxyglucose Standardised uptake value |
author_facet |
Shea Roddy Thomas Biggans Ahmad K. Raofi Avinash Kanodia Thiru Sudarshan Prasad Guntur Ramkumar |
author_sort |
Shea Roddy |
title |
Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital |
title_short |
Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital |
title_full |
Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital |
title_fullStr |
Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital |
title_full_unstemmed |
Prevalence of incidental thyroid malignancy on routine 18F-fluorodeoxyglucose PET-CT in a large teaching hospital |
title_sort |
prevalence of incidental thyroid malignancy on routine 18f-fluorodeoxyglucose pet-ct in a large teaching hospital |
publisher |
SpringerOpen |
series |
European Journal of Hybrid Imaging |
issn |
2510-3636 |
publishDate |
2020-11-01 |
description |
Abstract Purpose To quantify incidental thyroid pathology including malignancy on routine 18F-FDG PET-CT scans To compare standardised uptake values (SUVmax) in thyroid malignancy subtypes Methods and materials This is a retrospective study of all 18F-FDG PET-CT scans (n = 6179) performed in a teaching hospital between June 2010 and May 2019. RIS database search of reports for the word “thyroid” was performed. Studies with evidence of thyroid uptake were included. Patient age and gender, primary indication for PET scan (malignant or non-malignant), thyroid result on PET (diffuse or focal tracer uptake, SUVmax), ultrasound and FNAC results were recorded. Results Incidental abnormal thyroid tracer uptake as a proportion of all 18F-FDG PET-CT scans was 4.37% (n = 270). Out of region patients (n = 87) whose records could not be obtained were excluded leaving a study group of n = 183. Ninety-four in this group had focal uptake, and 89 had diffuse uptake. Fifty-five patients in the focal group had undergone further investigations. Of these, 30 were thought to be benign on USS alone, and 25 patients underwent USS/FNAC. Thirteen (24%) malignancies were identified (5 papillary, 6 follicular, 1 poorly differentiated thyroid cancer, 1 metastatic malignancy). Mean SUVmax for papillary carcinoma was noted to be 8.2 g/ml, and follicular carcinoma was 12.6 g/ml. Conclusion Incidental abnormal thyroid 18F-FDG PET-CT uptake in PET-CT scans of 4.37% is in keeping with the known limited literature. Rather similar number of patients was noted in the focal and diffuse tracer uptake categories in the final study group. Around quarter of the focal lesions were identified to be malignant, implying focal lesions should always be further investigated. |
topic |
Thyroid malignancy Hybrid imaging Positron emission tomography computed tomography 18-Fluorodeoxyglucose Standardised uptake value |
url |
http://link.springer.com/article/10.1186/s41824-020-00089-5 |
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