Melatonin, leptin, and ghrelin levels in nurses working night shifts
Aim: The levels of several hormones including melatonin, leptin, and ghrelin are regulated by circadian rhythm. Deregulated hormone levels due to disruption of circadian rhythm may result in medical conditions like metabolic syndrome (MetS). The aim of this cross-sectional study was to investigate t...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Journal of Surgery and Medicine
2019-01-01
|
Series: | Journal of Surgery and Medicine |
Subjects: | |
Online Access: | https://dergipark.org.tr/en/pub/josam/issue/42845/443902 |
id |
doaj-7b8db424f4644881b0acf3fb3571a812 |
---|---|
record_format |
Article |
spelling |
doaj-7b8db424f4644881b0acf3fb3571a8122021-05-20T06:35:08ZengJournal of Surgery and MedicineJournal of Surgery and Medicine2602-20792019-01-0131222610.28982/josam.4439021122Melatonin, leptin, and ghrelin levels in nurses working night shiftsBekir Çakır0Burçak Polat1Ercan Şimşek2Ayşe Banu Çaycı Sivri3Sibel Söylemez4ANKARA ATATÜRK EĞİTİM VE ARAŞTIRMA HASTANESİ, ENDOKRİNOLOJİ VE METABOLİZMA HASTALIKLARIANKARA ATATÜRK EĞİTİM VE ARAŞTIRMA HASTANESİ, ENDOKRİNOLOJİ VE METABOLİZMA HASTALIKLARIGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALIGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALIGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALIAim: The levels of several hormones including melatonin, leptin, and ghrelin are regulated by circadian rhythm. Deregulated hormone levels due to disruption of circadian rhythm may result in medical conditions like metabolic syndrome (MetS). The aim of this cross-sectional study was to investigate the associations among circadian rhythm, melatonin, leptin, ghrelin and metabolic syndrome by determining melatonin levels of healthy nurses who were working on night-shift for at least 3 months and of those on day-shift for at least 3 months.Methods: Venous bloods following 8-hour fasting of 50 nurses, who were aged at 20-40 age range and whose Body Mass Index (BMI) were >25, were collected. Those working on night-shift were named as night group and the control group of the study was named as day group. From the bloods collected; melatonin, leptin and ghrelin levels were evaluated by ELISA method, insulin was evaluated by immunochemically, whereas fasting blood glucose, cholesterol, triglyceride, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were evaluated spectrophotometrically.Results: Melatonin level was significantly lower in the night-shift group compared to the day-shift group (p=0.003). Leptin level was slightly but not significantly lower in the night-shift group (p=0.097). In contrast, ghrelin level and other biochemical parameters including triglyceride, fasting blood sugar (FBS), insulin, insulin resistance index (HOMA-IR) and cholesterol were increased in the night-shift group but these increments were not statistically significant.Conclusion: Our results suggest that night-shift work might exhibit tendency towards MetS by disrupting circadian rhythm.https://dergipark.org.tr/en/pub/josam/issue/42845/443902night shiftmetabolic syndromemelatoninleptinghrelingece vardiyasımetabolik sendrommelatoninleptingrelin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bekir Çakır Burçak Polat Ercan Şimşek Ayşe Banu Çaycı Sivri Sibel Söylemez |
spellingShingle |
Bekir Çakır Burçak Polat Ercan Şimşek Ayşe Banu Çaycı Sivri Sibel Söylemez Melatonin, leptin, and ghrelin levels in nurses working night shifts Journal of Surgery and Medicine night shift metabolic syndrome melatonin leptin ghrelin gece vardiyası metabolik sendrom melatonin leptin grelin |
author_facet |
Bekir Çakır Burçak Polat Ercan Şimşek Ayşe Banu Çaycı Sivri Sibel Söylemez |
author_sort |
Bekir Çakır |
title |
Melatonin, leptin, and ghrelin levels in nurses working night shifts |
title_short |
Melatonin, leptin, and ghrelin levels in nurses working night shifts |
title_full |
Melatonin, leptin, and ghrelin levels in nurses working night shifts |
title_fullStr |
Melatonin, leptin, and ghrelin levels in nurses working night shifts |
title_full_unstemmed |
Melatonin, leptin, and ghrelin levels in nurses working night shifts |
title_sort |
melatonin, leptin, and ghrelin levels in nurses working night shifts |
publisher |
Journal of Surgery and Medicine |
series |
Journal of Surgery and Medicine |
issn |
2602-2079 |
publishDate |
2019-01-01 |
description |
Aim: The levels of several hormones including melatonin, leptin, and ghrelin are regulated by circadian rhythm. Deregulated hormone levels due to disruption of circadian rhythm may result in medical conditions like metabolic syndrome (MetS). The aim of this cross-sectional study was to investigate the associations among circadian rhythm, melatonin, leptin, ghrelin and metabolic syndrome by determining melatonin levels of healthy nurses who were working on night-shift for at least 3 months and of those on day-shift for at least 3 months.Methods: Venous bloods following 8-hour fasting of 50 nurses, who were aged at 20-40 age range and whose Body Mass Index (BMI) were >25, were collected. Those working on night-shift were named as night group and the control group of the study was named as day group. From the bloods collected; melatonin, leptin and ghrelin levels were evaluated by ELISA method, insulin was evaluated by immunochemically, whereas fasting blood glucose, cholesterol, triglyceride, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were evaluated spectrophotometrically.Results: Melatonin level was significantly lower in the night-shift group compared to the day-shift group (p=0.003). Leptin level was slightly but not significantly lower in the night-shift group (p=0.097). In contrast, ghrelin level and other biochemical parameters including triglyceride, fasting blood sugar (FBS), insulin, insulin resistance index (HOMA-IR) and cholesterol were increased in the night-shift group but these increments were not statistically significant.Conclusion: Our results suggest that night-shift work might exhibit tendency towards MetS by disrupting circadian rhythm. |
topic |
night shift metabolic syndrome melatonin leptin ghrelin gece vardiyası metabolik sendrom melatonin leptin grelin |
url |
https://dergipark.org.tr/en/pub/josam/issue/42845/443902 |
work_keys_str_mv |
AT bekircakır melatoninleptinandghrelinlevelsinnursesworkingnightshifts AT burcakpolat melatoninleptinandghrelinlevelsinnursesworkingnightshifts AT ercansimsek melatoninleptinandghrelinlevelsinnursesworkingnightshifts AT aysebanucaycısivri melatoninleptinandghrelinlevelsinnursesworkingnightshifts AT sibelsoylemez melatoninleptinandghrelinlevelsinnursesworkingnightshifts |
_version_ |
1721435905054474240 |