Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex
Background: The dorsolateral prefrontal cortex (DLPFC) in both hemispheres have a central integrative function for motor control and behavior. Understanding the hemispheric difference between DLPFC and ipsilateral motor cortex connection in the resting-state will provide fundamental knowledge to exp...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-06-01
|
Series: | Frontiers in Human Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2020.00202/full |
id |
doaj-7b9a7b8e08344c5ea989718053e89981 |
---|---|
record_format |
Article |
spelling |
doaj-7b9a7b8e08344c5ea989718053e899812020-11-25T03:11:18ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612020-06-011410.3389/fnhum.2020.00202516880Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor CortexYanqiu Wang0Yanqiu Wang1Yanqiu Wang2Na Cao3Na Cao4Yitong Lin5Robert Chen6Robert Chen7Jian Zhang8School of Psychology, Shanghai University of Sport, Shanghai, ChinaKrembil Research Institute, University Health Network, Toronto, ON, CanadaDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, CanadaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaDepartment of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, JapanSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaKrembil Research Institute, University Health Network, Toronto, ON, CanadaDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, CanadaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaBackground: The dorsolateral prefrontal cortex (DLPFC) in both hemispheres have a central integrative function for motor control and behavior. Understanding the hemispheric difference between DLPFC and ipsilateral motor cortex connection in the resting-state will provide fundamental knowledge to explain the different roles DLPFC plays in motor behavior.Purpose: The current study tested the interactions between the ipsilateral DLPFC and the primary motor cortex (M1) in each hemisphere at rest. We hypothesized that left DLPFC has a greater inhibitory effect on the ipsilateral M1 compared to the right DLPFC.Methods: Fourteen right-handed subjects were tested in a dual-coil paired-pulse paradigm using transcranial magnetic stimulation. The conditioning stimulus (CS) was applied to the DLPFC and the test stimulus (TS) was applied to M1. Interstimulus intervals (ISIs) between CS and TS were 2, 4, 6, 8, 10, 15, 20, 25, and 30 ms. The result was expressed as a percentage of the mean peak-to-peak amplitude of the unconditioned test pulse.Results: There was stronger inhibitory effect for the left compared to the right hemisphere at ISIs of 2 (p = 0.045), 10 (p = 0.006), 15 (p = 0.029) and 20 (p = 0.024) ms. There was no significant inhibition or facilitation at any ISI in the right hemisphere.Conclusions: The two hemispheres have distinct DLPFC and M1 cortico-cortical connectivity at rest. Left hemisphere DLPFC is dominant in inhibiting ipsilateral M1.https://www.frontiersin.org/article/10.3389/fnhum.2020.00202/fulldorsolateral prefrontal cortexprimary motor cortexfunctional connectivityhemispheric differencestranscranial magnetic stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanqiu Wang Yanqiu Wang Yanqiu Wang Na Cao Na Cao Yitong Lin Robert Chen Robert Chen Jian Zhang |
spellingShingle |
Yanqiu Wang Yanqiu Wang Yanqiu Wang Na Cao Na Cao Yitong Lin Robert Chen Robert Chen Jian Zhang Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex Frontiers in Human Neuroscience dorsolateral prefrontal cortex primary motor cortex functional connectivity hemispheric differences transcranial magnetic stimulation |
author_facet |
Yanqiu Wang Yanqiu Wang Yanqiu Wang Na Cao Na Cao Yitong Lin Robert Chen Robert Chen Jian Zhang |
author_sort |
Yanqiu Wang |
title |
Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex |
title_short |
Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex |
title_full |
Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex |
title_fullStr |
Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex |
title_full_unstemmed |
Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex |
title_sort |
hemispheric differences in functional interactions between the dorsal lateral prefrontal cortex and ipsilateral motor cortex |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2020-06-01 |
description |
Background: The dorsolateral prefrontal cortex (DLPFC) in both hemispheres have a central integrative function for motor control and behavior. Understanding the hemispheric difference between DLPFC and ipsilateral motor cortex connection in the resting-state will provide fundamental knowledge to explain the different roles DLPFC plays in motor behavior.Purpose: The current study tested the interactions between the ipsilateral DLPFC and the primary motor cortex (M1) in each hemisphere at rest. We hypothesized that left DLPFC has a greater inhibitory effect on the ipsilateral M1 compared to the right DLPFC.Methods: Fourteen right-handed subjects were tested in a dual-coil paired-pulse paradigm using transcranial magnetic stimulation. The conditioning stimulus (CS) was applied to the DLPFC and the test stimulus (TS) was applied to M1. Interstimulus intervals (ISIs) between CS and TS were 2, 4, 6, 8, 10, 15, 20, 25, and 30 ms. The result was expressed as a percentage of the mean peak-to-peak amplitude of the unconditioned test pulse.Results: There was stronger inhibitory effect for the left compared to the right hemisphere at ISIs of 2 (p = 0.045), 10 (p = 0.006), 15 (p = 0.029) and 20 (p = 0.024) ms. There was no significant inhibition or facilitation at any ISI in the right hemisphere.Conclusions: The two hemispheres have distinct DLPFC and M1 cortico-cortical connectivity at rest. Left hemisphere DLPFC is dominant in inhibiting ipsilateral M1. |
topic |
dorsolateral prefrontal cortex primary motor cortex functional connectivity hemispheric differences transcranial magnetic stimulation |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2020.00202/full |
work_keys_str_mv |
AT yanqiuwang hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT yanqiuwang hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT yanqiuwang hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT nacao hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT nacao hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT yitonglin hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT robertchen hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT robertchen hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex AT jianzhang hemisphericdifferencesinfunctionalinteractionsbetweenthedorsallateralprefrontalcortexandipsilateralmotorcortex |
_version_ |
1724655041018593280 |