15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL)
Objectives: The purpose of this study was to compare the effect of benidipine (calcium channel blocker) and losartan (angiotensin receptor blocker) on arterial stiffness and central blood pressure (BP) in mild to moderate essential hypertensives. Methods and Results: This 24 weeks, multi-center, op...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Atlantis Press
2009-10-01
|
Series: | Artery Research |
Online Access: | https://www.atlantis-press.com/article/125925809/view |
id |
doaj-7b9b906746294c8e9b05236ae922fe13 |
---|---|
record_format |
Article |
spelling |
doaj-7b9b906746294c8e9b05236ae922fe132020-11-25T03:00:57ZengAtlantis PressArtery Research 1876-44012009-10-013310.1016/j.artres.2009.06.02915. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL)Sang-Hyun IhmShung Chull ChaeDo Sun LimKee Sik KimDong Ju ChoiJong Won HaDong Soo KimKye Hun KimMyeong Chan ChoHui Kyung JeonSang Hong BaekObjectives: The purpose of this study was to compare the effect of benidipine (calcium channel blocker) and losartan (angiotensin receptor blocker) on arterial stiffness and central blood pressure (BP) in mild to moderate essential hypertensives. Methods and Results: This 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group study was designed as a noninferior study. Eligible patients (n=200) were randomly assigned to receive benidipine (n=101) or losartan (n=99). Radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressure, pulse wave velocity (PWV) and augmentation index (AIx). No significant differences were found in the mean changes in central BP between 2 groups [−16.66 (systolic BP)/−10.70 (diastolic BP) mmHg in the benidipine group and –18.44/−11.79 mmHg in the losartan group; P=NS]. The mean changes in central, brachial and femoral PWV were –0.06, +0.06 and −0.51m/sec for the benidipine group and −0.02, −0.15 and −0.06m/s for losartan group (respectively; P=NS). No significant differences were found in the mean changes in AIx between two groups [−5.46 in the benidipine group and −4.22 in the losartan group; P=NS]. Conclusion: The reduction in central BP after 24 weeks of benidipine was non-inferior to that of losartan in mild to moderate essential hypertensives. There were no significant different between two drugs in aspect of PWV and AIx. Both drugs had similar central BP lowering effect and affected similarly arterial stiffness.https://www.atlantis-press.com/article/125925809/view |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sang-Hyun Ihm Shung Chull Chae Do Sun Lim Kee Sik Kim Dong Ju Choi Jong Won Ha Dong Soo Kim Kye Hun Kim Myeong Chan Cho Hui Kyung Jeon Sang Hong Baek |
spellingShingle |
Sang-Hyun Ihm Shung Chull Chae Do Sun Lim Kee Sik Kim Dong Ju Choi Jong Won Ha Dong Soo Kim Kye Hun Kim Myeong Chan Cho Hui Kyung Jeon Sang Hong Baek 15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL) Artery Research |
author_facet |
Sang-Hyun Ihm Shung Chull Chae Do Sun Lim Kee Sik Kim Dong Ju Choi Jong Won Ha Dong Soo Kim Kye Hun Kim Myeong Chan Cho Hui Kyung Jeon Sang Hong Baek |
author_sort |
Sang-Hyun Ihm |
title |
15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL) |
title_short |
15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL) |
title_full |
15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL) |
title_fullStr |
15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL) |
title_full_unstemmed |
15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL) |
title_sort |
15. open label, randomized, active drug comparative, parallel group, multi-center, phase iv study to compare the effect of benidipine and losartan on arterial stiffness and central blood pressure in mild to moderate essential hypertensive patients (belasco trial) |
publisher |
Atlantis Press |
series |
Artery Research |
issn |
1876-4401 |
publishDate |
2009-10-01 |
description |
Objectives: The purpose of this study was to compare the effect of benidipine (calcium channel blocker) and losartan (angiotensin receptor blocker) on arterial stiffness and central blood pressure (BP) in mild to moderate essential hypertensives.
Methods and Results: This 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group study was designed as a noninferior study. Eligible patients (n=200) were randomly assigned to receive benidipine (n=101) or losartan (n=99). Radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressure, pulse wave velocity (PWV) and augmentation index (AIx). No significant differences were found in the mean changes in central BP between 2 groups [−16.66 (systolic BP)/−10.70 (diastolic BP) mmHg in the benidipine group and –18.44/−11.79 mmHg in the losartan group; P=NS]. The mean changes in central, brachial and femoral PWV were –0.06, +0.06 and −0.51m/sec for the benidipine group and −0.02, −0.15 and −0.06m/s for losartan group (respectively; P=NS). No significant differences were found in the mean changes in AIx between two groups [−5.46 in the benidipine group and −4.22 in the losartan group; P=NS].
Conclusion: The reduction in central BP after 24 weeks of benidipine was non-inferior to that of losartan in mild to moderate essential hypertensives. There were no significant different between two drugs in aspect of PWV and AIx. Both drugs had similar central BP lowering effect and affected similarly arterial stiffness. |
url |
https://www.atlantis-press.com/article/125925809/view |
work_keys_str_mv |
AT sanghyunihm 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT shungchullchae 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT dosunlim 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT keesikkim 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT dongjuchoi 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT jongwonha 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT dongsookim 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT kyehunkim 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT myeongchancho 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT huikyungjeon 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial AT sanghongbaek 15openlabelrandomizedactivedrugcomparativeparallelgroupmulticenterphaseivstudytocomparetheeffectofbenidipineandlosartanonarterialstiffnessandcentralbloodpressureinmildtomoderateessentialhypertensivepatientsbelascotrial |
_version_ |
1724695801540640768 |