Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA genomes into host cell chromosomes. Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targeting are in...

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Bibliographic Details
Main Authors: Heather M Marshall, Keshet Ronen, Charles Berry, Manuel Llano, Heidi Sutherland, Dyana Saenz, Wendy Bickmore, Eric Poeschla, Frederic D Bushman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2129110?pdf=render

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