Bazedoxifene Attenuates Abdominal Aortic Aneurysm Formation via Downregulation of Interleukin-6/Glycoprotein 130/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Apolipoprotein E–Knockout Mice

Bazedoxifene Attenuates Abdominal Aortic Aneurysm Formation via Downregulation of Interleukin-6/Glycoprotein 130/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Apolipoprotein E–Knockout Mice

Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease characterized by aortic dilatation and predominantly affects an elderly population. Accumulating evidence suggests that Interleukin-6 (IL-6) and the signal transducer and activator of transcription 3 (STAT3) play an important role in...

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Bibliographic Details
Main Authors: Dan Yan, Haiyan Ma, Wei Shi, Pengcheng Luo, Tianshu Liu, Junyi Guo, Maocai Zhai, Jingwen Tao, Shengqi Huo, Chenglong Li, Jiayuh Lin, Sheng Li, Jiagao Lv, Cuntai Zhang, Li Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
abdominal aortic aneurysm
inflammation
bazedoxifene
IL-6
STAT3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00392/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00392/full

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