Hydralazine is a Suitable Mimetic Agent of Hypoxia to Study the Impact of Hypoxic Stress on In Vitro Blood-Brain Barrier Model

Hydralazine is a Suitable Mimetic Agent of Hypoxia to Study the Impact of Hypoxic Stress on In Vitro Blood-Brain Barrier Model

Background/Aims: Understanding cellular mechanisms induced by hypoxia is fundamental to reduce blood-brain barrier (BBB) disruption. Nevertheless, the investigation of hypoxia on cellular pathways is complex with true hypoxia because HIF-1α has a short lifetime and rapidly reverts back to a normoxic...

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Bibliographic Details
Main Authors: Morgane Chatard, Clémentine Puech, Nathalie Perek, Frédéric Roche
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
In Vitro model
Blood-brain barrier
CoCl2
Hydralazine
Hypoxia
Online Access:http://www.karger.com/Article/FullText/479399

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