Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects.

Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects.

CONTEXT: Expression and activity of the main lipogenic enzymes is paradoxically decreased in obesity, but the mechanisms behind these findings are poorly known. Breast Cancer 1 (BrCa1) interacts with acetyl-CoA carboxylase (ACC) reducing the rate of fatty acid biosynthesis. In this study, we aimed t...

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Bibliographic Details
Main Authors: Francisco J Ortega, José M Moreno-Navarrete, Dolores Mayas, Eva García-Santos, María Gómez-Serrano, José I Rodriguez-Hermosa, Bartomeu Ruiz, Wifredo Ricart, Francisco J Tinahones, Gema Frühbeck, Belen Peral, José M Fernández-Real
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3364252?pdf=render

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