In vivo outer hair cell length changes expose the active process in the cochlea.
Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required t...
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doaj-7ba65e1787184bd0845455e05c9d9cbd2020-11-25T01:30:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3275710.1371/journal.pone.0032757In vivo outer hair cell length changes expose the active process in the cochlea.Dingjun ZhaFangyi ChenSripriya RamamoorthyAnders FridbergerNiloy ChoudhurySteven L JacquesRuikang K WangAlfred L NuttallMammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required that the outer hair cells dynamically change their length, in addition to generating force. These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification.Using in vivo optical coherence tomography, we demonstrate that outer hair cells in living guinea pigs have length changes with unexpected timing and magnitudes that depend on the stimulus level in the sensitive cochlea.The level-dependent length change is a necessary condition for directly validating that power is expended by the active process presumed to underlie normal hearing.http://europepmc.org/articles/PMC3322117?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dingjun Zha Fangyi Chen Sripriya Ramamoorthy Anders Fridberger Niloy Choudhury Steven L Jacques Ruikang K Wang Alfred L Nuttall |
spellingShingle |
Dingjun Zha Fangyi Chen Sripriya Ramamoorthy Anders Fridberger Niloy Choudhury Steven L Jacques Ruikang K Wang Alfred L Nuttall In vivo outer hair cell length changes expose the active process in the cochlea. PLoS ONE |
author_facet |
Dingjun Zha Fangyi Chen Sripriya Ramamoorthy Anders Fridberger Niloy Choudhury Steven L Jacques Ruikang K Wang Alfred L Nuttall |
author_sort |
Dingjun Zha |
title |
In vivo outer hair cell length changes expose the active process in the cochlea. |
title_short |
In vivo outer hair cell length changes expose the active process in the cochlea. |
title_full |
In vivo outer hair cell length changes expose the active process in the cochlea. |
title_fullStr |
In vivo outer hair cell length changes expose the active process in the cochlea. |
title_full_unstemmed |
In vivo outer hair cell length changes expose the active process in the cochlea. |
title_sort |
in vivo outer hair cell length changes expose the active process in the cochlea. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required that the outer hair cells dynamically change their length, in addition to generating force. These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification.Using in vivo optical coherence tomography, we demonstrate that outer hair cells in living guinea pigs have length changes with unexpected timing and magnitudes that depend on the stimulus level in the sensitive cochlea.The level-dependent length change is a necessary condition for directly validating that power is expended by the active process presumed to underlie normal hearing. |
url |
http://europepmc.org/articles/PMC3322117?pdf=render |
work_keys_str_mv |
AT dingjunzha invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT fangyichen invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT sripriyaramamoorthy invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT andersfridberger invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT niloychoudhury invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT stevenljacques invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT ruikangkwang invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea AT alfredlnuttall invivoouterhaircelllengthchangesexposetheactiveprocessinthecochlea |
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