Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma
We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patient...
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doaj-7ba9fcd36bd14a4ca1eb8853f54746b32020-11-25T02:16:08ZengMDPI AGCancers2072-66942020-01-0112226210.3390/cancers12020262cancers12020262Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid CarcinomaSu Woong Yoo0Md. Sunny Anam Chowdhury1Subin Jeon2Sae-Ryung Kang3Sang-Geon Cho4Jahae Kim5Changho Lee6Young Jae Ryu7Ho-Chun Song8Hee-Seung Bom9Jung-Joon Min10Seong Young Kwon11Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Nuclear Medicine, Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaDepartment of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, KoreaWe investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups. Serum Tg was measured immediately before (D0Tg) and 7 days after RAI therapy (D7Tg). Patients were further categorized into favorable and unfavorable Tg groups based on the prediction of excellent response (ER) using scan-corrected Tg developed through the stepwise combination of D0Tg with ratio Tg (D7Tg/D0Tg). We investigated whether the predictive performance for ER improved with the application of scan-corrected Tg compared to the single Tg cutoff. The combined approach using scan-corrected Tg showed better predictive performance for ER than the single cutoff of D0Tg alone (<i>p </i>< 0.001). Therefore, scan-corrected Tg can be a promising biomarker to predict the therapeutic responses after RAI therapy.https://www.mdpi.com/2072-6694/12/2/262thyroglobulindifferentiated thyroid carcinomatherapeutic responseiodine scan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Su Woong Yoo Md. Sunny Anam Chowdhury Subin Jeon Sae-Ryung Kang Sang-Geon Cho Jahae Kim Changho Lee Young Jae Ryu Ho-Chun Song Hee-Seung Bom Jung-Joon Min Seong Young Kwon |
spellingShingle |
Su Woong Yoo Md. Sunny Anam Chowdhury Subin Jeon Sae-Ryung Kang Sang-Geon Cho Jahae Kim Changho Lee Young Jae Ryu Ho-Chun Song Hee-Seung Bom Jung-Joon Min Seong Young Kwon Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma Cancers thyroglobulin differentiated thyroid carcinoma therapeutic response iodine scan |
author_facet |
Su Woong Yoo Md. Sunny Anam Chowdhury Subin Jeon Sae-Ryung Kang Sang-Geon Cho Jahae Kim Changho Lee Young Jae Ryu Ho-Chun Song Hee-Seung Bom Jung-Joon Min Seong Young Kwon |
author_sort |
Su Woong Yoo |
title |
Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma |
title_short |
Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma |
title_full |
Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma |
title_fullStr |
Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma |
title_full_unstemmed |
Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma |
title_sort |
optimization of predictive performance for the therapeutic response using iodine scan-corrected serum thyroglobulin in patients with differentiated thyroid carcinoma |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-01-01 |
description |
We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups. Serum Tg was measured immediately before (D0Tg) and 7 days after RAI therapy (D7Tg). Patients were further categorized into favorable and unfavorable Tg groups based on the prediction of excellent response (ER) using scan-corrected Tg developed through the stepwise combination of D0Tg with ratio Tg (D7Tg/D0Tg). We investigated whether the predictive performance for ER improved with the application of scan-corrected Tg compared to the single Tg cutoff. The combined approach using scan-corrected Tg showed better predictive performance for ER than the single cutoff of D0Tg alone (<i>p </i>< 0.001). Therefore, scan-corrected Tg can be a promising biomarker to predict the therapeutic responses after RAI therapy. |
topic |
thyroglobulin differentiated thyroid carcinoma therapeutic response iodine scan |
url |
https://www.mdpi.com/2072-6694/12/2/262 |
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