Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease
PurposeVitamin D is associated with various pathological conditions such as cardiovascular diseases and cancer. We investigated the relationship between vitamin D and Kawasaki disease (KD).MethodsWe performed a retrospective review of the medical records of patients with KD between February 2013 and...
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doaj-7bb9d84c244248799fa2ce18e3d4aa482020-11-24T22:37:37ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582017-07-0160721622010.3345/kjp.2017.60.7.21620125550660Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki diseaseJae Sung Jun0Young Kwon Jung1Dong Won Lee2Department of Pediatrics, Daegu Fatima Hospital, Daegu, Korea.Department of Pediatrics, Daegu Fatima Hospital, Daegu, Korea.Department of Pediatrics, Daegu Fatima Hospital, Daegu, Korea.PurposeVitamin D is associated with various pathological conditions such as cardiovascular diseases and cancer. We investigated the relationship between vitamin D and Kawasaki disease (KD).MethodsWe performed a retrospective review of the medical records of patients with KD between February 2013 and March 2016 in Daegu Fatima Hospital. Study participants were grouped according to vitamin D serum concentration. Group 1 included patients with 25(OH)-vitamin D ≥20 ng/mL. Group 2 included patients with 25(OH)-vitamin D <20 ng/mL. We analyzed the clinical characteristics and laboratory data of the 2 groups.ResultsOf the 91 patients, 52 were included in group 1, and 39 in group 2. Group 1 patients had significantly higher levels of calcium, phosphate, albumin and sodium than group 2 patients did. There were no differences in clinical characteristics, but the proportion of patients with polymorphic rash was significantly higher in group 2. Resistance to intravenous immunoglobulin was more frequent in group 2 (P=0.023). No significant difference in the incidence of coronary artery complications was observed.ConclusionLow vitamin D levels are associated with resistance to intravenous immunoglobulin therapy in KD. Vitamin D deficiency might be a risk factor for immunoglobulin resistance in KD.http://kjp.or.kr/upload/pdf/kjped-60-216.pdfVitamin DKawasaki diseaseInflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jae Sung Jun Young Kwon Jung Dong Won Lee |
spellingShingle |
Jae Sung Jun Young Kwon Jung Dong Won Lee Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease Korean Journal of Pediatrics Vitamin D Kawasaki disease Inflammation |
author_facet |
Jae Sung Jun Young Kwon Jung Dong Won Lee |
author_sort |
Jae Sung Jun |
title |
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease |
title_short |
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease |
title_full |
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease |
title_fullStr |
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease |
title_full_unstemmed |
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease |
title_sort |
relationship between vitamin d levels and intravenous immunoglobulin resistance in kawasaki disease |
publisher |
Korean Pediatric Society |
series |
Korean Journal of Pediatrics |
issn |
1738-1061 2092-7258 |
publishDate |
2017-07-01 |
description |
PurposeVitamin D is associated with various pathological conditions such as cardiovascular diseases and cancer. We investigated the relationship between vitamin D and Kawasaki disease (KD).MethodsWe performed a retrospective review of the medical records of patients with KD between February 2013 and March 2016 in Daegu Fatima Hospital. Study participants were grouped according to vitamin D serum concentration. Group 1 included patients with 25(OH)-vitamin D ≥20 ng/mL. Group 2 included patients with 25(OH)-vitamin D <20 ng/mL. We analyzed the clinical characteristics and laboratory data of the 2 groups.ResultsOf the 91 patients, 52 were included in group 1, and 39 in group 2. Group 1 patients had significantly higher levels of calcium, phosphate, albumin and sodium than group 2 patients did. There were no differences in clinical characteristics, but the proportion of patients with polymorphic rash was significantly higher in group 2. Resistance to intravenous immunoglobulin was more frequent in group 2 (P=0.023). No significant difference in the incidence of coronary artery complications was observed.ConclusionLow vitamin D levels are associated with resistance to intravenous immunoglobulin therapy in KD. Vitamin D deficiency might be a risk factor for immunoglobulin resistance in KD. |
topic |
Vitamin D Kawasaki disease Inflammation |
url |
http://kjp.or.kr/upload/pdf/kjped-60-216.pdf |
work_keys_str_mv |
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