Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV)...

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Main Authors:	Zai-Bo Yang, Pei Li, Yin-Ju He
Format:	Article
Language:	English
Published:	MDPI AG 2019-10-01
Series:	Molecules
Subjects:	isoxazole-amide acylhydrazone synthesis antiviral activity
Online Access:	https://www.mdpi.com/1420-3049/24/20/3766

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spelling	doaj-7bbacf956cd34403b2b86889e3caae202020-11-24T22:10:24ZengMDPI AGMolecules1420-30492019-10-012420376610.3390/molecules24203766molecules24203766Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral AgentsZai-Bo Yang0Pei Li1Yin-Ju He2School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, ChinaSchool of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, ChinaSchool of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, ChinaAs a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Antiviral bioassays indicated that some of the target compounds exhibited better in vivo antiviral activities against TMV and CMV than those of Ningnanmycin (NNM). Especially, the compound <b>7t</b> exhibited the best curative, protection, and inactivation activities against TMV and CMV which were superior to those of NNM. Meanwhile, our present work also revealed that compound <b>7t</b> could enhance the defense-related enzyme activity and increase the chlorophyll content in tobacco leaves to induce resistance and enhance plant tolerance to TMV infection.https://www.mdpi.com/1420-3049/24/20/3766isoxazole-amideacylhydrazonesynthesisantiviral activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zai-Bo Yang Pei Li Yin-Ju He
spellingShingle	Zai-Bo Yang Pei Li Yin-Ju He Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents Molecules isoxazole-amide acylhydrazone synthesis antiviral activity
author_facet	Zai-Bo Yang Pei Li Yin-Ju He
author_sort	Zai-Bo Yang
title	Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents
title_short	Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents
title_full	Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents
title_fullStr	Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents
title_full_unstemmed	Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents
title_sort	design, synthesis, and bioactivity evaluation of novel isoxazole-amide derivatives containing an acylhydrazone moiety as new active antiviral agents
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-10-01
description	As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Antiviral bioassays indicated that some of the target compounds exhibited better in vivo antiviral activities against TMV and CMV than those of Ningnanmycin (NNM). Especially, the compound <b>7t</b> exhibited the best curative, protection, and inactivation activities against TMV and CMV which were superior to those of NNM. Meanwhile, our present work also revealed that compound <b>7t</b> could enhance the defense-related enzyme activity and increase the chlorophyll content in tobacco leaves to induce resistance and enhance plant tolerance to TMV infection.
topic	isoxazole-amide acylhydrazone synthesis antiviral activity
url	https://www.mdpi.com/1420-3049/24/20/3766
work_keys_str_mv	AT zaiboyang designsynthesisandbioactivityevaluationofnovelisoxazoleamidederivativescontaininganacylhydrazonemoietyasnewactiveantiviralagents AT peili designsynthesisandbioactivityevaluationofnovelisoxazoleamidederivativescontaininganacylhydrazonemoietyasnewactiveantiviralagents AT yinjuhe designsynthesisandbioactivityevaluationofnovelisoxazoleamidederivativescontaininganacylhydrazonemoietyasnewactiveantiviralagents
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Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

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