Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1

Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1

Leptin directly activates macrophages and lymphocytes, but the role of leptin in neutrophil activation and migration is still controversial. Here, we investigate the in vivo mechanisms of neutrophil migration induced by leptin. The intraperitoneal injection of leptin (1 mg/kg) induces a time- and co...

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Bibliographic Details
Main Authors: Glaucia Souza-Almeida, Heloisa D’Avila, Patricia E. Almeida, Tatiana Luna-Gomes, Sally Liechocki, Barbara Walzog, Ingrid Hepper, Hugo Caire Castro-Faria-Neto, Patricia T. Bozza, Christianne Bandeira-Melo, Clarissa M. Maya-Monteiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
leptin
neutrophil
inflammation
tumor necrosis factor-alpha
CXCL1
leukotriene B4
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00111/full

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