Methyl 1-(7-acetamido-5,8-dimethoxyquinolin-2-yl)-4-methyl-β-carboline-3-carboxylate
The title compound, C27H24N4O5, is an intermediate in the synthesis of lavendamycin via a ruthenium-catalysed [2 + 2 + 2] cycloaddition. An intramolecular hydrogen-bond bridge from the carboline to the quinoline stabilizes a highly planar geometry...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Union of Crystallography
2011-06-01
|
| Series: | Acta Crystallographica Section E |
| Online Access: | http://scripts.iucr.org/cgi-bin/paper?S1600536811018794 |
| Summary: | The title compound, C27H24N4O5, is an intermediate in the synthesis of lavendamycin via a ruthenium-catalysed [2 + 2 + 2] cycloaddition. An intramolecular hydrogen-bond bridge from the carboline to the quinoline stabilizes a highly planar geometry [maximum deviation = 0.065 (6) Å] for the two rigid units. This hydrogen-bond-stabilized coplanarity has a very close analogy in the structure of the antitumor antibiotic streptonigrin in the solid state and in solution. Intermolecular hydrogen-bond bridges of amides groups along the a axis and π–π stacking interactions [centroid–centroid distance = 3.665 (9) Å] connect molecules arranged in a parallel manner. |
|---|---|
| ISSN: | 1600-5368 |