Peculiarities of intrauterine pathological processes in women of the postmenopauseal period
Aim of the research is studying the pecularities of the endometrium pathological processes in postmenopausal women on the basis of the hysteroscopy data evaluation, as well as conduction of histopathological and immunochemical studies. Materials and methods. To study the pecularities of intrauter...
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2021-05-01
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Online Access: | http://journal.eu-jr.eu/health/article/view/1853 |
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doaj-7bcec5b01a7b426ca0fe542f86f288b22021-06-01T08:45:16ZengScientific Route OÜEUREKA: Health Sciences2504-56602504-56792021-05-013162310.21303/2504-5679.2021.0018531853Peculiarities of intrauterine pathological processes in women of the postmenopauseal periodTetiana Polishchuk0Serhii Vdovichenko1Oleksandra Lubkovska2Dmytro Ledin3Shupyk National Healthcare University of UkraineShupyk National Healthcare University of UkraineShupyk National Healthcare University of UkraineShupyk National Healthcare University of UkraineAim of the research is studying the pecularities of the endometrium pathological processes in postmenopausal women on the basis of the hysteroscopy data evaluation, as well as conduction of histopathological and immunochemical studies. Materials and methods. To study the pecularities of intrauterine pathological processes, 100 postmenopausal women were selected and studied. All women underwent hysteroscopy with separate diagnostic scraping of the uterine cavity. Also, 10 samples of glandular-fibrous endometrial polyps (GFEP) in women of reproductive age and 9 samples of such pathology in the postmenopausal period were studied by immunohistochemical method, using 6 primary specific monoclonal antibodies. Results. The results showed that in 64 (64 %) postmenopausal women pathological changes of the endometrium were presented with GFEP, and in 2 patients (2 %) endometrial adenocarcinoma was found. It was also determined that the nuclei of epithelial and stromal cells of GFEP in postmenopausal women are characterized by lower expression of estrogen and progesterone receptors, compared with women with such formations in the reproductive age. In addition, it was found that in postmenopausal women the expression of the apoptosis inhibitor bcl-2 and aromatase P450 in the epithelial and stromal cells of GFEP was more expressed, and the expression of the Bах antigen, on the contrary, was significantly lower than in women of reproductive age. Conclusions. Fundamental molecular-biological differences of GFEP in postmenopausal women compared with women of reproductive age were revealed. It was found that in postmenopausal women there is a significantly lower dependence of such polyps on the effects of estrogen and progesterone. In addition, the data indicate an increased risk of neoplastic transformation in such women.http://journal.eu-jr.eu/health/article/view/1853postmenopausepathological process of the endometriumglandular-fibrous endometrial polypendometrial adenocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tetiana Polishchuk Serhii Vdovichenko Oleksandra Lubkovska Dmytro Ledin |
spellingShingle |
Tetiana Polishchuk Serhii Vdovichenko Oleksandra Lubkovska Dmytro Ledin Peculiarities of intrauterine pathological processes in women of the postmenopauseal period EUREKA: Health Sciences postmenopause pathological process of the endometrium glandular-fibrous endometrial polyp endometrial adenocarcinoma |
author_facet |
Tetiana Polishchuk Serhii Vdovichenko Oleksandra Lubkovska Dmytro Ledin |
author_sort |
Tetiana Polishchuk |
title |
Peculiarities of intrauterine pathological processes in women of the postmenopauseal period |
title_short |
Peculiarities of intrauterine pathological processes in women of the postmenopauseal period |
title_full |
Peculiarities of intrauterine pathological processes in women of the postmenopauseal period |
title_fullStr |
Peculiarities of intrauterine pathological processes in women of the postmenopauseal period |
title_full_unstemmed |
Peculiarities of intrauterine pathological processes in women of the postmenopauseal period |
title_sort |
peculiarities of intrauterine pathological processes in women of the postmenopauseal period |
publisher |
Scientific Route OÜ |
series |
EUREKA: Health Sciences |
issn |
2504-5660 2504-5679 |
publishDate |
2021-05-01 |
description |
Aim of the research is studying the pecularities of the endometrium pathological processes in postmenopausal women on the basis of the hysteroscopy data evaluation, as well as conduction of histopathological and immunochemical studies.
Materials and methods. To study the pecularities of intrauterine pathological processes, 100 postmenopausal women were selected and studied. All women underwent hysteroscopy with separate diagnostic scraping of the uterine cavity. Also, 10 samples of glandular-fibrous endometrial polyps (GFEP) in women of reproductive age and 9 samples of such pathology in the postmenopausal period were studied by immunohistochemical method, using 6 primary specific monoclonal antibodies.
Results. The results showed that in 64 (64 %) postmenopausal women pathological changes of the endometrium were presented with GFEP, and in 2 patients (2 %) endometrial adenocarcinoma was found. It was also determined that the nuclei of epithelial and stromal cells of GFEP in postmenopausal women are characterized by lower expression of estrogen and progesterone receptors, compared with women with such formations in the reproductive age. In addition, it was found that in postmenopausal women the expression of the apoptosis inhibitor bcl-2 and aromatase P450 in the epithelial and stromal cells of GFEP was more expressed, and the expression of the Bах antigen, on the contrary, was significantly lower than in women of reproductive age.
Conclusions. Fundamental molecular-biological differences of GFEP in postmenopausal women compared with women of reproductive age were revealed. It was found that in postmenopausal women there is a significantly lower dependence of such polyps on the effects of estrogen and progesterone. In addition, the data indicate an increased risk of neoplastic transformation in such women. |
topic |
postmenopause pathological process of the endometrium glandular-fibrous endometrial polyp endometrial adenocarcinoma |
url |
http://journal.eu-jr.eu/health/article/view/1853 |
work_keys_str_mv |
AT tetianapolishchuk peculiaritiesofintrauterinepathologicalprocessesinwomenofthepostmenopausealperiod AT serhiivdovichenko peculiaritiesofintrauterinepathologicalprocessesinwomenofthepostmenopausealperiod AT oleksandralubkovska peculiaritiesofintrauterinepathologicalprocessesinwomenofthepostmenopausealperiod AT dmytroledin peculiaritiesofintrauterinepathologicalprocessesinwomenofthepostmenopausealperiod |
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1721410939753857024 |