Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.

Bibliographic Details
Main Authors: Tianxiao Huan, Roby Joehanes, Ci Song, Fen Peng, Yichen Guo, Michael Mendelson, Chen Yao, Chunyu Liu, Jiantao Ma, Melissa Richard, Golareh Agha, Weihua Guan, Lynn M. Almli, Karen N. Conneely, Joshua Keefe, Shih-Jen Hwang, Andrew D. Johnson, Myriam Fornage, Liming Liang, Daniel Levy
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12228-z

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