Origin, function and role in the development of skin diseases CLA+T-lymphocytes

• Main Authors: A. V. Patrushev, A. V. Samtsov, V. Yu. Nikitin, A. М. Ivanov, O. Р. Gumilevskaya, A. V. Sukharev, I. A. Sukhina
• Format: Article
• Language: Russian
• Published: State Scientific Center of Dermatovenereology and Cosmetology 2018-08-01
• Series: Vestnik Dermatologii i Venerologii
• Subjects: cla; cutaneous lymphocyte antigen; t-memory cells; t-cell-mediated diseases; psoriasis; atopic dermatitis; skin lymphomas
• Online Access: https://www.vestnikdv.ru/jour/article/view/401

The idea of CLA+T-lymphocytes, which are a special subpopulation of cells with a tropic to the skin, is given. The issues of maturation, migration and functional features of CLA+T-cells are considered. Special attention is paid to the different phenotype of memory T-cells. Modern data concerning the role of CLA+T-cells in the pathogenesis of autoimmune and allergic dermatoses, as well as malignant skin tumors are also presented. The conclusion about the necessity of further study of CLA +T-lymphocytes for detailed understanding of pathogenesis and search of variants of targeted therapy in psoriasis, atopic dermatitis, skin lymphomas and other skin diseases is made.