Adenosquamous carcinoma of the lung
Chenghui Li,1,2 Hongyang Lu2,3 1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, People’s Republic of China; 2Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China; 3Zhejian...
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doaj-7be7c5b07d004185845d2eca992018392020-11-24T23:14:19ZengDove Medical PressOncoTargets and Therapy1178-69302018-08-01Volume 114829483539864Adenosquamous carcinoma of the lungLi CLu HChenghui Li,1,2 Hongyang Lu2,3 1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, People’s Republic of China; 2Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China; 3Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China Abstract: Adenosquamous carcinoma of the lung (ASC), a relatively rare subtype of non-small-cell lung cancer, is defined as a malignancy containing components of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC). Although ASC has biological characteristics of ADC and SCC, it is not by any means a simple hybrid of two components above. It is extremely difficult to diagnose preoperatively; pathology of surgically resected gross specimen is the most effective means for adequate diagnosis of ASC. Platinum-based postoperative adjuvant chemotherapy for at least four cycles can significantly improve the survival in stage III patients with ASC. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib and gefitinib can be the effective therapeutic strategies for advanced EGFR-mutant ASC. The studies of crizotinib in the treatment of patients with ASC are very limited. Immune checkpoint blockade therapy may be a potential treatment choice for ASC patients. Keywords: adenosquamous carcinoma of the lung, clinicopathological characteristics, histogenesis, prognosis, chemotherapy, targeted therapy, immunotherapyhttps://www.dovepress.com/adenosquamous-carcinoma-of-the-lung-peer-reviewed-article-OTTadenosquamous carcinoma of the lungclinicopathologic characteristicshistogenesisprognosischemotherapytargeted therapyimmunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li C Lu H |
spellingShingle |
Li C Lu H Adenosquamous carcinoma of the lung OncoTargets and Therapy adenosquamous carcinoma of the lung clinicopathologic characteristics histogenesis prognosis chemotherapy targeted therapy immunotherapy |
author_facet |
Li C Lu H |
author_sort |
Li C |
title |
Adenosquamous carcinoma of the lung |
title_short |
Adenosquamous carcinoma of the lung |
title_full |
Adenosquamous carcinoma of the lung |
title_fullStr |
Adenosquamous carcinoma of the lung |
title_full_unstemmed |
Adenosquamous carcinoma of the lung |
title_sort |
adenosquamous carcinoma of the lung |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2018-08-01 |
description |
Chenghui Li,1,2 Hongyang Lu2,3 1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang province, People’s Republic of China; 2Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China; 3Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China Abstract: Adenosquamous carcinoma of the lung (ASC), a relatively rare subtype of non-small-cell lung cancer, is defined as a malignancy containing components of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC). Although ASC has biological characteristics of ADC and SCC, it is not by any means a simple hybrid of two components above. It is extremely difficult to diagnose preoperatively; pathology of surgically resected gross specimen is the most effective means for adequate diagnosis of ASC. Platinum-based postoperative adjuvant chemotherapy for at least four cycles can significantly improve the survival in stage III patients with ASC. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib and gefitinib can be the effective therapeutic strategies for advanced EGFR-mutant ASC. The studies of crizotinib in the treatment of patients with ASC are very limited. Immune checkpoint blockade therapy may be a potential treatment choice for ASC patients. Keywords: adenosquamous carcinoma of the lung, clinicopathological characteristics, histogenesis, prognosis, chemotherapy, targeted therapy, immunotherapy |
topic |
adenosquamous carcinoma of the lung clinicopathologic characteristics histogenesis prognosis chemotherapy targeted therapy immunotherapy |
url |
https://www.dovepress.com/adenosquamous-carcinoma-of-the-lung-peer-reviewed-article-OTT |
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