Kidney disease and hemodialysis: identification of blood biomarkers to detect heart failure and kidney failure

• Main Authors: Barbara Letícia Dudel Mayer, Pollyana Thays Lameira da Costa, Maria Elena Echevarría-Guanilo, Silvana Silveira Kempfer, Kleber Maciel da Silva Pieri
• Format: Article
• Language: English
• Published: Asociación Colombiana de Nefrología e Hipertensión Arterial 2020-08-01
• Series: Revista Colombiana de Nefrología
• Subjects: chronicrenalinsufficiency; renaldialysis; biomarkers; clinicalalarms; diagnostictechniquesandprocedures(mesh)
• Online Access: https://revistanefrologia.org/index.php/rcn/article/view/382
• ISSN: 2500-5006

Introduction:Chronichemodialysisaimstoreplacerenalfunctionandprovidesanextensionoflifeexpectancy,however,complications dooccurandtheycan be seriousevenfatal.Knowingthe complicationscan enableabetterprognosticevaluationanduseofan interventionapproach.Thesecanbeidentifiedwhenperforminganamnesisandphysicalexamination, aswellas,withgreater precision,bymeansofrenalandcardiacbiomarkersandimagingtests.Objectives: toidentifyvalidbloodbiomarkerstodetectheartfailureandkidneyfailureassociatedwithkidneydiseaseand hemodialysis.Methods:systematicliteraturereviewconductedinAugust2018inthefollowing:WebOfScience,PubMed,Scopus,Cinahal, Cochrane,ScienceDirectandLilacs.Theguidingquestionwas:“Whatarethebloodbiomarkersusedtodetectheartfailureand kidneyfailure?”Atotalof537publicationswerefound,94oftheseappearedmorethanonce,383wereexcludedafterreadingtitles andabstracts,32wereexcludedafterreadingthefulltexts,and10wereexcludedinthequantitativeandqualitativesynthesis. Results:18paperscomposethefinalsampleandreportlaboratoryandimagingtests,instrumentstoassesstheriskofkidneyand heartfailure,andalsoclinicalmanagementoftheprogressionofkidneyandheartfailure.Allthestudiescorrelatedriskofmortality anddeathoutcome.Conclusion:laboratorytestsareimportanttoidentifyingkidneyandheartfailureandneedtobeusedtoimproveclinicalmanagementofthehemodialysistreatmentofpeoplewithchronickidneydiseaseinordertoimprovequalityoflifeandlifeexpectancy