Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors
Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects by reducing glutamate receptor function, but...
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doaj-7bff4441996245ffb0219a7c0d3f21c12020-11-24T20:46:35ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-04-011310.3389/fncel.2019.00168447810Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate ReceptorsYongjun Sun0Yongjun Sun1Xue Feng2Yue Ding3Mengting Li4Jun Yao5Long Wang6Zibin Gao7Zibin Gao8Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, ChinaHebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, ChinaHebei University of Science and Technology, Shijiazhuang, ChinaShijiazhuang Vocational College of Technology and Information, Shijiazhuang, ChinaDepartment of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, ChinaDepartment of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, ChinaDepartment of Family and Consumer Sciences, California State University, Long Beach, CA, United StatesDepartment of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, ChinaState Key Laboratory Breeding Base—Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, ChinaExtracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects by reducing glutamate receptor function, but none have been successful. In this minireview, we present the available evidence regarding the role of all types of ionotropic and metabotropic glutamate receptors in cerebral ischemia and propose phased treatment strategies based on glutamate receptors in both the acute and post-acute phases of cerebral ischemia, which may help realize the clinical application of glutamate receptor antagonists.https://www.frontiersin.org/article/10.3389/fncel.2019.00168/fullcerebral ischemiaexcitotoxicityphased treatment strategiesglutamate receptorsglutamate receptor antagonist |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yongjun Sun Yongjun Sun Xue Feng Yue Ding Mengting Li Jun Yao Long Wang Zibin Gao Zibin Gao |
spellingShingle |
Yongjun Sun Yongjun Sun Xue Feng Yue Ding Mengting Li Jun Yao Long Wang Zibin Gao Zibin Gao Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors Frontiers in Cellular Neuroscience cerebral ischemia excitotoxicity phased treatment strategies glutamate receptors glutamate receptor antagonist |
author_facet |
Yongjun Sun Yongjun Sun Xue Feng Yue Ding Mengting Li Jun Yao Long Wang Zibin Gao Zibin Gao |
author_sort |
Yongjun Sun |
title |
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors |
title_short |
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors |
title_full |
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors |
title_fullStr |
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors |
title_full_unstemmed |
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors |
title_sort |
phased treatment strategies for cerebral ischemia based on glutamate receptors |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2019-04-01 |
description |
Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects by reducing glutamate receptor function, but none have been successful. In this minireview, we present the available evidence regarding the role of all types of ionotropic and metabotropic glutamate receptors in cerebral ischemia and propose phased treatment strategies based on glutamate receptors in both the acute and post-acute phases of cerebral ischemia, which may help realize the clinical application of glutamate receptor antagonists. |
topic |
cerebral ischemia excitotoxicity phased treatment strategies glutamate receptors glutamate receptor antagonist |
url |
https://www.frontiersin.org/article/10.3389/fncel.2019.00168/full |
work_keys_str_mv |
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