ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population

ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population

Abstract Background ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to inhibit Wnt/β-catenin signaling pathway, ICG-001 has been used in some t...

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Bibliographic Details
Main Authors: Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma, Lisong Shen
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ICG-001
Gastric cancer
Wnt/β-catenin signaling pathway
Growth
Stem cell-like
Online Access:http://link.springer.com/article/10.1186/s13046-017-0595-0

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