METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Pharmaceutical treatment of coronary heart disease (CHD) should be able to solve the key task – reduction of myocardial oxygen demand, or improvement of oxygen supply via vasodilatation. Currently, metabolic therapy of CHD is of particular interest, since it can reduce myocardial oxygen demand and s...

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Main Authors: V. B. Simonenko, A. P. Golikov, A. A. Spassky
Format: Article
Language:Russian
Published: «FIRMA «SILICEA» LLC  2010-10-01
Series:Российский кардиологический журнал
Subjects:
Online Access:https://russjcardiol.elpub.ru/jour/article/view/1501
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spelling doaj-7c23475323f941ada4f81b4cab8e82a02021-07-28T14:02:14Zrus«FIRMA «SILICEA» LLC Российский кардиологический журнал1560-40712618-76202010-10-010591971288METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTIONV. B. Simonenko0A. P. Golikov1A. A. Spassky2Центральный военный госпиталь им П.В. МандрыкиНИИ СП им. Н.В.СклифосовскогоНациональное агентство клинической фармакологии и фармации, МоскваPharmaceutical treatment of coronary heart disease (CHD) should be able to solve the key task – reduction of myocardial oxygen demand, or improvement of oxygen supply via vasodilatation. Currently, metabolic therapy of CHD is of particular interest, since it can reduce myocardial oxygen demand and substantially increase the effectiveness of oxygen utilisation in myocardial ischemia settings. The study was aimed at investigating the effectiveness of pre-hospital therapy with a cytoprotector mexicor, with subsequent intracoronary mexicor administration in the first hours of acute myocardial infarction (AMI). In total, 112 AMI patients, hospitalised no later than 4 hours after AMI onset, were included in the study. Successful angioplasty of infarct-related coronary artery (IRCA) and intracoronary administration of a cardio-protector mexicor were associated with a substantial improvement in clinical effectiveness of coronary blood flow normalisation and prevention of myocardial reperfusion injury.https://russjcardiol.elpub.ru/jour/article/view/1501coronary heart diseasemetabolic therapyangioplastyinfarct-related coronary arteryintracoronary administrationmyocardial reperfusion injury
collection DOAJ
language Russian
format Article
sources DOAJ
author V. B. Simonenko
A. P. Golikov
A. A. Spassky
spellingShingle V. B. Simonenko
A. P. Golikov
A. A. Spassky
METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Российский кардиологический журнал
coronary heart disease
metabolic therapy
angioplasty
infarct-related coronary artery
intracoronary administration
myocardial reperfusion injury
author_facet V. B. Simonenko
A. P. Golikov
A. A. Spassky
author_sort V. B. Simonenko
title METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_short METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_full METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_fullStr METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_full_unstemmed METABOLIC THERAPY EFFECTS ON CORONARY BLOOD FLOW IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
title_sort metabolic therapy effects on coronary blood flow in patients with acute myocardial infarction
publisher «FIRMA «SILICEA» LLC 
series Российский кардиологический журнал
issn 1560-4071
2618-7620
publishDate 2010-10-01
description Pharmaceutical treatment of coronary heart disease (CHD) should be able to solve the key task – reduction of myocardial oxygen demand, or improvement of oxygen supply via vasodilatation. Currently, metabolic therapy of CHD is of particular interest, since it can reduce myocardial oxygen demand and substantially increase the effectiveness of oxygen utilisation in myocardial ischemia settings. The study was aimed at investigating the effectiveness of pre-hospital therapy with a cytoprotector mexicor, with subsequent intracoronary mexicor administration in the first hours of acute myocardial infarction (AMI). In total, 112 AMI patients, hospitalised no later than 4 hours after AMI onset, were included in the study. Successful angioplasty of infarct-related coronary artery (IRCA) and intracoronary administration of a cardio-protector mexicor were associated with a substantial improvement in clinical effectiveness of coronary blood flow normalisation and prevention of myocardial reperfusion injury.
topic coronary heart disease
metabolic therapy
angioplasty
infarct-related coronary artery
intracoronary administration
myocardial reperfusion injury
url https://russjcardiol.elpub.ru/jour/article/view/1501
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