Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study
Despoina Kalapanida,1 Flora Zagouri,1 Maria Gazouli,2 Andriani Tsiakou,3 Eleni Zografos,2 Constantine Dimitrakakis,4 Spyridon Marinopoulos,4 Aris Giannos,4 Theodoros N Sergentanis,1 Efstathios Kastritis,1 Evangelos Terpos,1 Meletios-Athanassios Dimopoulos11Department of Clinical Therapeutic, Alexand...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2019-05-01
|
Series: | OncoTargets and Therapy |
Subjects: | |
Online Access: | https://www.dovepress.com/evaluation-of-met-t1010i-and-met-rs40239-single-nucleotide-polymorphis-peer-reviewed-article-OTT |
id |
doaj-7c2c44055200422ca4d752f6a5b02bd5 |
---|---|
record_format |
Article |
spelling |
doaj-7c2c44055200422ca4d752f6a5b02bd52020-11-25T02:12:00ZengDove Medical PressOncoTargets and Therapy1178-69302019-05-01Volume 124195420246102Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control studyKalapanida DZagouri FGazouli MTsiakou AZografos EDimitrakakis CMarinopoulos SGiannos ASergentanis TNKastritis ETerpos EDimopoulos MADespoina Kalapanida,1 Flora Zagouri,1 Maria Gazouli,2 Andriani Tsiakou,3 Eleni Zografos,2 Constantine Dimitrakakis,4 Spyridon Marinopoulos,4 Aris Giannos,4 Theodoros N Sergentanis,1 Efstathios Kastritis,1 Evangelos Terpos,1 Meletios-Athanassios Dimopoulos11Department of Clinical Therapeutic, Alexandra Hospital, Medical School, University of Athens, Athens, Greece; 2Department of Basic Medical Sciences, Laboratory of Biology, University of Athens School of Medicine and Laboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; 3First Department of Dermatology, Syggros Hospital, University of Athens School of Medicine, Athens, Greece; 4Department of Obstetrics and Gynaecology, Alexandra Hospital, Medical School, University of Athens, Athens, GreeceAim: The purpose of this study is to evaluate the role of MET T1010I and MET rs40239 as potential risk factor and/or prognostic markers in patients with triple-negative breast cancer (TNBC).Methods: 114 samples of DNA from paraffin-embedded breast normal tissues of patients with TNBC and 124 samples of healthy controls were collected and analyzed for MET T1010I and MET rs40239 polymorphisms.Results: MET T1010I CT genotype was associated with increased risk of TNBC in both univariate and multivariate analysis. The status of rs40239 was not associated with a higher risk for TNBC at either the univariate or the multivariate analysis. None of the examined polymorphisms was associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR=1.35, 95% CI: 0.31–5.97 for MET T1010I CT/TT vs CC; adjusted HR=1.78, 95% CI: 0.73–4.35 for rs40239 AG/GG vs AA).Conclusion: Our case–control study suggests that MET T1010I seems to be a risk factor for TNBC in the Caucasian Greek population, in contrast with MET rs40239, where no correlation was found.Keywords: SNPS, MET T1010I, MET rs40239, triple-negative breast cancer, biomarkerhttps://www.dovepress.com/evaluation-of-met-t1010i-and-met-rs40239-single-nucleotide-polymorphis-peer-reviewed-article-OTTSNPSMET T1010IMET rs40239triple negative breast cancerbiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kalapanida D Zagouri F Gazouli M Tsiakou A Zografos E Dimitrakakis C Marinopoulos S Giannos A Sergentanis TN Kastritis E Terpos E Dimopoulos MA |
spellingShingle |
Kalapanida D Zagouri F Gazouli M Tsiakou A Zografos E Dimitrakakis C Marinopoulos S Giannos A Sergentanis TN Kastritis E Terpos E Dimopoulos MA Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study OncoTargets and Therapy SNPS MET T1010I MET rs40239 triple negative breast cancer biomarker |
author_facet |
Kalapanida D Zagouri F Gazouli M Tsiakou A Zografos E Dimitrakakis C Marinopoulos S Giannos A Sergentanis TN Kastritis E Terpos E Dimopoulos MA |
author_sort |
Kalapanida D |
title |
Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study |
title_short |
Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study |
title_full |
Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study |
title_fullStr |
Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study |
title_full_unstemmed |
Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study |
title_sort |
evaluation of met t1010i and met rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case–control study |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2019-05-01 |
description |
Despoina Kalapanida,1 Flora Zagouri,1 Maria Gazouli,2 Andriani Tsiakou,3 Eleni Zografos,2 Constantine Dimitrakakis,4 Spyridon Marinopoulos,4 Aris Giannos,4 Theodoros N Sergentanis,1 Efstathios Kastritis,1 Evangelos Terpos,1 Meletios-Athanassios Dimopoulos11Department of Clinical Therapeutic, Alexandra Hospital, Medical School, University of Athens, Athens, Greece; 2Department of Basic Medical Sciences, Laboratory of Biology, University of Athens School of Medicine and Laboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; 3First Department of Dermatology, Syggros Hospital, University of Athens School of Medicine, Athens, Greece; 4Department of Obstetrics and Gynaecology, Alexandra Hospital, Medical School, University of Athens, Athens, GreeceAim: The purpose of this study is to evaluate the role of MET T1010I and MET rs40239 as potential risk factor and/or prognostic markers in patients with triple-negative breast cancer (TNBC).Methods: 114 samples of DNA from paraffin-embedded breast normal tissues of patients with TNBC and 124 samples of healthy controls were collected and analyzed for MET T1010I and MET rs40239 polymorphisms.Results: MET T1010I CT genotype was associated with increased risk of TNBC in both univariate and multivariate analysis. The status of rs40239 was not associated with a higher risk for TNBC at either the univariate or the multivariate analysis. None of the examined polymorphisms was associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR=1.35, 95% CI: 0.31–5.97 for MET T1010I CT/TT vs CC; adjusted HR=1.78, 95% CI: 0.73–4.35 for rs40239 AG/GG vs AA).Conclusion: Our case–control study suggests that MET T1010I seems to be a risk factor for TNBC in the Caucasian Greek population, in contrast with MET rs40239, where no correlation was found.Keywords: SNPS, MET T1010I, MET rs40239, triple-negative breast cancer, biomarker |
topic |
SNPS MET T1010I MET rs40239 triple negative breast cancer biomarker |
url |
https://www.dovepress.com/evaluation-of-met-t1010i-and-met-rs40239-single-nucleotide-polymorphis-peer-reviewed-article-OTT |
work_keys_str_mv |
AT kalapanidad evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT zagourif evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT gazoulim evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT tsiakoua evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT zografose evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT dimitrakakisc evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT marinopouloss evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT giannosa evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT sergentanistn evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT kastritise evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT terpose evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy AT dimopoulosma evaluationofmett1010iandmetrs40239singlenucleotidepolymorphismsintriplenegativebreastcanceracasendashcontrolstudy |
_version_ |
1724911297601994752 |